摘要
目的 观察苯那普利联合小剂量氢氯噻嗪治疗原发性轻中度高血压的疗效。方法 原发性高血压 75例分为 ,对照组 (n =35)服苯那普利 ,心功能Ⅲ级者予西地兰速尿 ,地高辛。合并冠心病者予鲁南欣康 ;治疗组 (n=40 )在对照组基础上加氢氯噻嗪 ,疗程均 6周 ,观察其对血压、心功能、KFG、代谢、电解质的影响。结果 两组的血压均明显下降 ,有效有显著差异 (P <0 .0 5) ;心功能改善率有显著差异 (P <0 .0 5) ,ST -T改善无显著差异 (P >0 .0 5) ,对代谢 ,电解质无影响。结论 两药联合治疗原发性轻中度高血压 ,方便、有效、安全、适合作一线的联合用药方案。
Objective To observe the effect of Benazapril in combination with low dose of Hydrochlorothiazide on essential hypertension. Methods 75 patients with hypertension divided into 2 groups randomly. 35 patients with hypertension in control group were treated with Benazapril. The patients with third grade cardiac function were added cedilanid, furosemide and digoxin. The patients complicated with coronary artery disease were added Lunanxinkang. In addition to these treatments, 40 patients in experimental group were treated with low dose of Hydrochlorothiazide. After 6 weeks treatment, the change of blood pressure, cardiac function, EKG, metabolism, blood electrolyte were recorded. Results The blood pressure lower significantly in the two groups (P<0.05). There was significant difference in blood pressure, cardiac function between two groups. There was no significant difference in ST-T of EKG between two groups. The treatment influenced metabolism and electrolyte little. Conclusions The treatment of benazapril in combination with low dose of Hydrochlorothiazide on essential hypertension is convenient, effective and safe. It should be considered as the first therapeutic scheme.
出处
《实用全科医学》
2004年第6期540-541,共2页
Applied Journal Of General Practice
关键词
苯那普利
联合用药
剂量
氢氯噻嗪
高血压
Benazapril
Low dose of Hydrochlorothiazide
Hypertension
Cardiac function
