摘要
目的 探讨cTnI、TNFα和CRP在乙型病毒性肝炎心肌损伤中的应用价值及相关研究。方法 序贯搜集整理 4 2 0例乙肝住院和门诊患者的ALT和TBIL资料检测 339例cTnI,分为cTnI阳性组和阴性组 ,按随机选出标本检测TNFα和CRP。结果 cTnI总阳性率为 16 2 % (5 5 / 339)。急性、慢性轻度、慢性中度、慢性重度及肝炎肝硬化患者cTnI阳性分别为 18 5 % (5 / 2 2 )、 11 5 % (17/ 135 )、 19 5 % (17/ 70 )、 2 4 5 % (12 / 3)和 16 7%(4 / 2 0 ) ,均大于正常对照组。除慢性重度和慢性轻度差异有显著性意义外 (P =0 0 2 1) ,余各型肝炎差异均无显著性意义。其中 ,cTnI阳性组和cTnI阴性组患者 ,ALT、TBIL、TNFα和CRP与正常对照组相比差异有显著性意义 (P <0 0 5 ) ,cTnI阳性组与阴性组相比差异有显著性意义 (P <0 0 5 )。结论 乙型病毒性肝炎的心肌损伤程度与患者临床类型有关 ,与TNFα、CRP和TBIL有关 。
Objective To explore the Correlation between serum C-reactive protein(CRP), Tumor necrosis factor-α(TNFα) and cardiac impairment in patients with hepatitis B and the mechanism of myocardium impairment in patients with hepatitis B.Methods Serum troponin I concentrations were measured in 339 continuous patients with hepatitis B by an enzyme-linked immunosorbent assay(ELISA) and clinic data were also collected .First,we divided patients with hepatitis B into 5 groups,which group (Ⅰ) is 27 patients with acute hepatitis B ,group(Ⅱ) is 152 patients with mild chronic hepatitis B,group (Ⅲ) is 87 patients with moderate chronic hepatitis B,group (Ⅳ) is 49 patients with severe chronic hepatitis B ,group (Ⅴ) is 24 patients with cirrhosis of hepatitis B and control group.second,we divided patients into positive serum troponin I and negative one and serum ALT,TBILαand CRP were detected.Restlt The total positive rate was 16.2%(55/339).The positive rates of serum troponin I were 18.5%(5/22)?11.5%(17/135)?19.5%(17/70)?24.5%(12/3) and 16.7%(4/20) in groupⅠ,groupⅡ,groupⅢ,groupⅣand groupⅤrespectively.All of them were higher than control group(0.6%).There were significant difference in groups Ⅳ vs group Ⅰ (P=0.021) and no significant difference in the others among all hepatitis B groups.There were significant difference in the values of alanine aminotransferase (ALT),total bilirubin (TBIL) ,TNFαand CRP (positive serum troponin I concentrations vs negative one,P<0.05) .Conclusion myocardium impairment in hepatitis B patients is related to the state of illness of hepatitis B and to the mediums of inflammation.It suggests that TBIL and inflammation factors such as C-reactive protein and Tumor necrosis factor-αmight play an important role in myocardium impairments in hepatitis B patients.
出处
《邯郸医学高等专科学校学报》
2004年第5期375-377,共3页
Journal of Handan Medical College
