摘要
目的 应用判别分析确定WHO神经行为核心测试组合 (WHO/NCTB)检测职业性铅接触人群的关键测验项目。方法 对某蓄电池厂 135名铅作业工人及 14 3名非铅接触者进行WHO/NCTB的测试。结果 血铅平均水平为 4 2 1.5 μg/L时 ,铅作业工人的消极情感和积极情感与对照组比较均有显著性差异 ;神经行为指标中的倒序数字广度 (DSPB)、数字广度(DSP)、提转捷度 (SAN)、习惯用手提转捷度 (SANP)、非习惯用手提转捷度 (SANN)、数字译码 (DSY)、目标追踪正确数(PAC)、目标追踪错误数 (PAE)也有显著性改变。逐步判别法建立的由忧郁 -沮丧 (POMSD)、有力 -好动 (POMSV)、简单反应时最快值 (SRTF)、倒序数字广度 (DSPB)、目标追踪正确数 (PAC)和目标追踪错误数 (PAE) 6项指标组成的判别函数与直接判别法建立的由WHO/NCTB所有指标组成的判别函数的回判效果相近。结论 血铅水平刚高于 4 0 0 μg/L时就可引起神经行为功能的改变。WHO/NCTB的POMSD、POMSV、SRTF、DSPB、PAC和PAE 6项指标是检测铅作业工人神经行为功能的关键项目。
Objective To determine key sub-tests of WHO neurobehavioral core test battery (WHO/NCTB) testing the lead-exposed workers by discrimination analysis. Methods Lead-exposed workers (n=135)in a storage battery plant and normal controls(n=143) were tested by WHO/NCTB. Results Positive mood and negative mood were found to be significantly different between lead-exposed workers and control group at blood Pb level of 421.5 μg/L. Part of neurobehavioral indexes were also found to be significantly changed, including error dot number(PAE),dignity span backward(DSPB),dignity span(DSP),Santa Ana(SAN),Santa Ana practice hand(SANP),Santa Ana non-practice hand(SANN),digit synbol(DSY) and correct dot number(PAC). The percentage of cases correctly classified by function composed of 6 sub-tests: depression-dejection (POMSD),vigor-activigy (POMSV),fastest simple reaction(SRTF),DSPB,PAC and PAE,using stepwise procedure was similar to that of cases correctly classified by discrimination function of all tests using direct method. Conclusion Neurobehavior function is impaired when the level of blood Pb is just above 400 μg/L. It shows that POMSD,POMSV,SRTF,DSPB,PAC and PAE of WHO/NCTB seem to be key sub-tests for detecting the neurobehavior function of lead-exposed workers.
出处
《山西医科大学学报》
CAS
2004年第5期473-475,共3页
Journal of Shanxi Medical University
关键词
铅
铅中毒
神经行为核心测试组合
判别分析
关键测试项目
lead
lead poisoning
neurobehavioral core test battery
discrimination analysis
key sub-tests
