摘要
目的 探讨鱼精蛋白在体外循环心内直视术中再灌注期的低血压效应及其机制。方法 连续选取先天性心脏病患儿 2 3名 ,分别于体外循环直视手术中 ,鱼精蛋白给予前 1min ,给予后 5min ,30min ,测定右心房血NO的含量。同时监测平均动脉压 (MAP)的变化。结果 有 7名患儿发生低血压反应 (MAP≥ 10mmHg) ,伴随NO2 -/NO3 -含量较给药前明显增高(P <0 .0 5 ) ,与正常组相比差异有显著性 (P <0 .0 1)。结论 鱼精蛋白参与心肌再灌注期低血压反应的发生 ,其机制可能与短暂性NO的大量产生有关。
Objective To investigate the hypotension effects after protamine administration during myocardial reperfusion period in open heart surgery, with an emphasis on defining the role of the nitrous oxide (NO). Methods Twenty-three children with the congenital heart disease were investigated. NO was taken from right artrial blood and mean arterial pressure(MAP) were measured 1 min before and 5 min,30 min after the protamine administration in open heart surgery. Results Following protamine administration, NO 2 -/NO 3 - level in 7 patients was increased with MAP significant decline compared with control group. Conclusion These results suggest that the phenomenon of hypotension after protamine administration may be induced in part by the production of a great quantity of NO, which results in dilation of the vessel.
出处
《山西医科大学学报》
CAS
2004年第5期495-496,共2页
Journal of Shanxi Medical University
关键词
体外循环
心肌再灌注
鱼精蛋白
低血压
extracorporeal circulation
myocardial reperfusion
protamine
hypotension
