摘要
目的 研究血清脂蛋白 (a) [Lipoprotein(a)Lpa)在脑梗塞形成中的作用及意义。 方法 采用免疫透射比浊法检测血清中LP(a)的浓度。 结果 脑梗塞组LP(a)浓度为 ( 0 .40± 0 .2 5 )g/L显著高于对照组的 ( 0 .2 2± 0 .15 )g/L) (P <0 0 1) ,复发脑梗塞与初发脑梗塞比较 ,血LP(a)含量及LP(a)增高发生率亦显著高于初发脑梗塞组 (P <0 0 5 ,P <0 0 5 ) ,神经功能缺损评分值与LP (a)水平含量呈正相关 ,LP(a)水平与年龄、血压、胆固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白胆固醇无关 (P >O 0 5 )。 结论 LP (a)为一独立的致脑梗塞危险因素 ,同时亦是脑梗塞复发的重要危险因素之一 ,其含量可做为判断病情轻重的客观指标之一 ,且对有缺血性中风倾向病人测定LP(a)含量可推测其患病风险和对已发生脑梗死者 ,可推测其再发可能性。
Objective To evaluate the effects and significance of lipoprein(a) on the development of cerebral infarcfion(CI). Methods Serum concentrations of LP(a) Levers were measured by immunoassay of transmittamce. Results The median Values of LP(a) in brain infarction group(n=68)were significantly higher than the control group(n=45)(P<0.01). Serum concentration of Lp(a) Levers and the rate of high concentration of LP(a) occurring were significantly higher in recurrent cerebral infarction than in initial cerebral infarction(P<0.05,P<0.05).The values of the neural function defect marked were higher with the higher of the concentrations of LP(a) levers. LP(a) was not relative to age, hypotension, cholesterol, TRIG, HOL-D.LDL. Conclusion First, LP(a)was not only an independent risk factors of cerebral infarction, but also one of the important risk factor of recurrent cerebral infarction. Second, LP(a)could be an index of determing the disease which was serious or not serious. Third, The concentrations of LP(a) levels can be used to predict the risk of stroke, and the possibility of cerebral infarction recurrence.
出处
《中国热带医学》
CAS
2004年第5期733-735,共3页
China Tropical Medicine
