摘要
目的 观察利维爱及补肾中药对绝经后骨质疏松症的防治作用。方法 对 35例绝经妇女每日顿服利维爱 1 2 5mg ,34例绝经妇女口服强骨胶囊 1粒 /次 ,3次 /d。观察其治疗前后临床症状 ,骨密度及代谢生化指标及副作用。结果 服药前后两组临床症状均明显改善 ,骨密度有所上升。利维爱组尿Ca/Cr、尿HOP/Cr、血Ca水平明显改善 ,补肾中药组骨代谢生化指标改善不明显 ,但利维爱组副作用较补肾中药组大。结论 直接应用性激素治疗组在防治绝经后骨质疏松方面效果更显著 ,补肾中药组在改善症状及维持骨量方面疗效显著且副作用小 ,对用性激素替代治疗有禁忌或顾虑及不能耐受其副作用的患者 ,是一种有效的治疗途径。
Objective To compare livial and kidney-invigorating traditional Chinese medicine in postmenopausal osteoporosis. Methods 35 postmenopausal women took 1.25 mg livial daily and 34 postmenopausal women took 3 Qianggu capsules daily. Then we observed their clinical symptoms, bone mineral density (BMD), bone biochemical index and side effect.Results The clinical symptoms in both groups were improved remarkable. BMD increased significantly in livial group, but not significantly in traditional Chinese medicine group. Urine calcium creatinine ratio (Ca/Cr), hydroxyproline creatinine ratio (HOP/Cr), and serum calcium in livial group were improved markedly, but did not change significantly in traditional Chinese medicine group. However, the side effect in livial group is greater. Conclusions Livial has evident effect on bone metabolism indices. Traditional Chinese medicine remarkably relieves clinical symptoms, maintains bone quantity, and has less side effect. Hence, kidney-invigorating traditional Chinese medicine is reummended instead of hormone in patients not fit for hormone replacement therapy.
出处
《中国骨质疏松杂志》
CAS
CSCD
2004年第3期337-339,共3页
Chinese Journal of Osteoporosis
