摘要
①目的 探讨糖尿病肾病 (DN)病人早期尿视黄醇结合蛋白 (RBP)的变化及意义。②方法 采用免疫速率散射比浊法和免疫透射比浊法 ,检测了 98例糖尿病 (DM )病人 (其中无DN病人 4 1例 ,早期DN病人 32例 ,临床DN病人 2 5例 )和 87例正常人 2 4h尿清蛋白排泄率 (UAE)、转铁蛋白 (TRF)、β2 微球蛋白 (β2 M )和RBP的含量。③结果 DM病人、无DN病人、早期DN病人、临床DN病人的UAE、TRF、β2 M和RBP明显高于对照组 ,差异有显著性 (F =11.75～ 87.6 8,q =8.97～ 32 .96 ,P <0 .0 1)。早期DN病人较无DN病人上述指标明显升高(q =11.2 1～ 2 6 .2 0 ,P <0 .0 1) ,临床DN组较早期DN组上述指标明显升高 (q =12 .4 3～ 31.5 6 ,P <0 .0 1)。DN病人的RBP与UAE、TRF和 β2 M呈显著正相关 (r =0 .5 5 1～ 0 .978,P <0 .0 1)。④结论 尿RBP增高可反映DN早期肾小管功能损害 。
Objective To explore the changes and significance of retinol-binding protein(RBP) in early diabetic nephropathy(DN). Methods The urine album excretion rate(UAE), the contents of transferring(TRF), β 2-microglobulin(β 2-M) and RBP were determined in 87 normal controls and 98 diabetes mellitus(DM) patients(no DN, 41 patients; early DN, 32; and clinical DN, 25) by immune rate scatter nephelometry and immune transmission nephelometry. Results The levels of UAE, TRF, β 2-M and RBP in patients with DM, no DN, early DN, and clinical DN groups were significantly higher than those in the control group(F=11.75-87.68,q=8.97-32.96, P<0.01); in early DN group than those in no DN group (q=11.21-26.20,P< 0.01); and in clinical DN group than in early DN group (q=12.43-31.56,P<0.01).Urine RBP had significantly positive correlation with UAE, TRF and β 2-M (r=0.551-0.978,P<0.01). Conclusion The increase of urine RBP reflects the damage of renal tubular function in early DN, which has an important value for its early diagnosis.
出处
《齐鲁医学杂志》
2004年第5期412-413,共2页
Medical Journal of Qilu
