摘要
目的 :观察丙泊酚联合应用不同剂量的芬太尼在人工流产手术中的麻醉效果。方法 :人工流产手术病人 15 0例 ,符合美国麻醉学家学会Ⅰ～Ⅱ级 ,分为 3组。A组单次静脉注射 (静注 )丙泊酚 2mg·kg- 1。B组单次静注丙泊酚 1.5mg·kg- 1及芬太尼 1μg·kg- 1。C组单次静注丙泊酚 1.5mg·kg- 1及芬太尼 2 μg·kg- 1。观察 3组病人麻醉起效及苏醒时间、丙泊酚总用量及呼吸抑制情况。结果 :麻醉起效时间B组为 (1.2±s 0 .4 )min ,C组为(1.3± 0 .4 )min ,明显快于A组 (1.8± 0 .7)min ,P <0 .0 1;意识恢复时间B组短于A组。丙泊酚用量B ,C组均少于A组。用药后SPO2 ,RR均下降 ,C组发生率明显高于A ,B两组。结论 :丙泊酚 1.5mg·kg- 1联合应用芬太尼 1μg·kg- 1用于人工流产手术麻醉是安全。
AIM: To observe anesthesia effects of propofol combined with different dose of fentany for artificial abortion. METHODS: One hundred and fifty patients of American Society of Anesthesiologists (ASA) Ⅰ-Ⅱ were randomly divided into three groups in equal number. Group A was intravenously injected with a loading dose of propofol 2 mg·kg -1. Group B was intravenously injected with a loading dose of propofol 1.5 mg·kg -1 and fentanyl 1 μg·kg -1. Group C was intravenously injected with a loading dose of propofol 1.5 mg·kg -1 and fentanyl 2 μg·kg -1. The propofol was injected slowly over 40-60 s. Then, in all 3 groups, the anesthesia of patients was maintained by injection of propofol as needed. The time of anesthesia time, consciousness recovery of patients, and total amount of propofol used in each patient in three groups were observed. RESULTS: The onset of anesthesia of patients was ( 1.2± s0.4) min in group B, ( 1.3 ±0.4) min in group C, significantly faster than that in group A ( 1.8 ±0.7) min (P <0.01). The consciousness recovery of patients in group B was sooner than that in group A (P <0.01). The total amount of propofol used in both group B and group C was less than that in group A. The incidence of SPO 2 and RR decreased after administration of anesthetic drugs, but it was higher in group C than that in group A and B (P< 0.01). CONCLUSIONS: Propofol 1.5 mg·kg -1 combined with fentanyl 1 μg·kg -1 is effective and safe for painless artificial abortion anesthesia.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2004年第10期705-708,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
丙泊酚
芬太尼
流产
人工
麻醉
静脉
propofol
fentanyl
abortion, induced
anesthesia, intravenous
