吡啶衍生物研究(IX):N-(1-甲氧羰基 )乙基 -N-[5-(2 -氯吡啶 -4-基 )-1 , 3 , 4-噻二唑 -2-基 ]酰胺的合成及除草活性(英文) 被引量：5

Synthesis and Herbicidal Activities of N-(1-Carbomethoxy)-ethyl-N-[5-(2-chloropyrid-4-yl)-1,3,4-thiodiazol-2-yl] Amides

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摘要为了进一步研究前期发现的除草先导化合物2-仲丁氨基-5-(2-氯吡啶-4-基)-1,3,4-噻二唑(BCPT)的结构-活性关系并提高其除草活性,设计并合成了一系列N-(1-甲氧羰基)乙基-N-[5-(2-氯吡啶-4-基)-1,3,4-噻二唑-2-基]酰胺类化合物。其苗后除草活性测定结果表明,所有化合物的活性都远低于BCPT本身。说明BCPT可能具有与传统酰胺类除草剂不同的作用机制。 In order to investigate the structure-activity relationship and improve the activity of (herbicidal) lead compound 2-sec-butylamino-5-(2-chloropyrid-4-yl)-1,3,4-thiodiazole (BCPT) which was found in previous work on pyridine derivatives, a novel series of N-(1-carbomethoxy)ethyl-N-[5-(2-chloropyrid-4-yl)-1,3,4-thiodiazol-2-yl] amides were synthesized and subjected to post-emergence herbicidal tests. All the compounds showed much weaker herbicidal activity than BCPT itself. The results suggested that BCPT might act to herbs in different way to amide (herbicides.)

作者车超肖玉梅毛淑芬覃兆海

机构地区中国农业大学理学院

出处《农药学学报》 CAS CSCD 2004年第3期15-20,共6页 Chinese Journal of Pesticide Science

关键词 1 3 4-噻二唑丙氨酸酯酰胺除草活性 1,3,4-thiodiazoles alaninate amides herbicidal activity

分类号 O621.29 [理学—有机化学]

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