摘要
目的 探讨PF方案联合放射治疗T3～ 4N0～ 1晚期鼻咽癌的疗效。方法 76例T3～ 4N0～ 1鼻咽癌分放、化疗组 (综合组 )、单放组 ;综合组联合DDP 30～ 4 0mg、5 -Fu 5 0 0～ 75 0mg同期化疗 ,每周一次 ,共 5～ 7次 ;综合组、对照组均采用后程超分割放疗 ,鼻咽部DT 74～ 80GY。结果 放疗后 6个月 ,综合组、对照组鼻咽肿物全消退率分别为 84 .6 1%、6 2 .16 % (P =0 .0 4 19) ,1、2、3年局控率分别为 10 0 .0 0 %、92 .30 %、74 .35 % ;10 0 .0 0 %、78.37%、5 1.35 % ,1、2、3年生存率分别为 92 .30 %、84 .6 1%、76 .92 % ;86 .4 8%、6 7.5 6 %、5 4 .0 5 % ;两组 1、2年局控率、生存率无差异 ;3年局控率、生存率综合组均较对照组高 ,有显著差异 (P <0 .0 5 )。结论 T3～ 4N0～ 1鼻咽癌应以局部控制为主 ,同期低剂量增敏化疗、后程超分割放疗有较好的疗效 ;
Objective To investigate the clinical effect of radiotherapy combined with chemotherapy on T_ 3～4 N_ 0～1 nasopharyngeal carcinoma patients.Methods Patients with T_ 3～4 N_ 0～1 were divided into radiotherapy combined with chemotherapy group ( study group)and radiotherapy group ( control group). Patients in study group were treated with radiotherapy combined with chemotherapy included cisplatin 30～40mg and 5-Fu 500～750mg, Once a week. All patients received late course hyperfractionated radiotherapy to a total doses of 74～80Gy in nasopharynx.Results Six months after radiotherapy, complete response(CR) rates of nasopharynx were 84.61% in study group and 62.16% in control group(P=0.0419). The 1, 2, 3-year local control rate were 100.00%, 92.30%, 74.35% and 100.00%, 78.37%, 51.35%, respectively. The 1, 2, 3-year survival rates were 92.30%, 84.61%, 76.92% and 86.48%, 67.56%, 54.05%, respectively. There were no significant difference between the two groups in the 1, 2-year local control and survival rates. The 3-year local control and survival rate of study group were higher than those of control group (P<0.05).Conclusion Local control was dominant for patients with T_ 3～4 N_ 0～1 , combination of low dose chemotherapy with late course hyperfractionated radiotherapy had better therapeutic effect.
出处
《现代肿瘤医学》
CAS
2004年第5期410-413,共4页
Journal of Modern Oncology
关键词
鼻咽肿瘤
放射治疗
化学治疗
超分割
顺铂
Nasopharyngeal carcinoma
Radiotherapy
Chemotherapy
Hyperfractionated radiotherapy
Cisplatin
