摘要
目的 采用吉西他滨联合氟尿嘧啶动静脉给药治疗晚期胰腺癌 ,观察疗效 ,生存时间及不良反应。方法 11例晚期胰腺癌患者第 1天经肝动脉及肠系膜上动脉灌注吉西他滨 10 0 0mg/m2 5 -FU6 0 0mg/m2 ,CF10 0mg ;第 2～ 5天外周静脉给药CF10 0mg(2小时 ) 5 -FU 6 0 0mg/m2 (4小时 ) ,第 8天外周静脉给药吉西他滨 10 0 0mg/m2 (30分钟 ) 3周一次 ,3个疗程。结果 客观有效率 2 7.3% ,临床获益率 81.8% ;疼痛缓解率达81.8%。中位生存期 11个月 ,其中 12个月以上 4 5 .5 % ,2 4个月以上 18.2 %。主要毒副反应为骨髓抑制 ,脱发及消化道反应。结论 吉西他滨联合氟尿嘧啶动静脉给药治疗晚期胰腺癌 ,在改善症状 ,延长生存期方面效果肯定 。
Objective The aim of the study was to assess the curative effect,survival time and toxicity of gemcitabine combine 5-fluorouracil by transcatheter arterial and intravenous infusion on advanced pancreatic cancer.Methods Eleven patients with advanced pancreatic cancer were given gemcitabine 1000mg/m^2,5-fluorouracil 600mg/m^2,CF 100 mg by arteria hepatica and arteria mesenterica superior infusion the first day, Then they were given CF 100 mg (two hours)5-fluorouracil 600mg/m^2(four hours)d2～d5,and gemcitabine 1000mg/m^2 d8 by intravenous infusion,21 days/cycle×3cycles.Results Objective relief rate 27.3%,clinical benefit rate(RR+SD)81.8%;pain relief rate 81.8%.The mean survival time was eleven month,and 45.5% more than 12 months 18.2% more than 24 months.The major toxicity was myelosuppression,alopecie and enteron reaction.Conclusion Transcatherer erterial and intravenous infusion of gemcitabine combine 5-fluorouracil improved symptom and prolonged lifetime of patients with advanced pancreatic cancer.The toxicity effects could be toleranced.
出处
《现代肿瘤医学》
CAS
2004年第5期435-436,共2页
Journal of Modern Oncology
关键词
吉西他滨
晚期胰腺癌
动静脉给药
gemicitabine
advanced pancreatic cancer
transcatheter arterial and intravenous infusion
