摘要
目的 :研究一氧化氮 (NO)在鼻咽癌血清中的浓度及其临床意义。方法 :用硝酸还原酶法测定健康人和鼻咽癌患者的血清NO3-和NO2-之和以反映体内一氧化氮水平。检测了不同临床分期的鼻咽癌患者4 0例 (原发于鼻咽顶壁区 18例 ,鼻咽侧壁区 2 2例。T119例 ,T2 11例 ,T3 7例 ,T43例 ;N0 2 7例 ,N19例 ,N2 4例 ;M0 34例 ,M16例 )放疗前后及 30例健康体检者血清一氧化氮含量。结果 :鼻咽癌患者血清一氧化氮含量显著高于健康人 ,前者为 111.16± 39.4 1μmol L ,后者仅为 6 8.6 4± 17.36 μmol L (P <0 .0 0 1) ,鼻咽癌患者放疗结束后 2周的血清一氧化氮含量为 87.81± 30 .5 4μmol L ,比放疗前明显降低 (P <0 .0 0 1) ,淋巴结转移组为 10 5 .31± 2 5 .18μmol L ,显著低于无淋巴结转移组的 12 1.74± 2 9.4 5 μmol L(P <0 .0 5 ) ,3年内死亡组为97.72± 2 9.4 5 μmol L ,显著低于存活组的 10 5 .31± 2 5 .18μmol L(P <0 .0 5 )。 结论 :鼻咽癌患者血清一氧化氮含量显著高于健康人 ,它可能在分子水平参与了鼻咽癌的发生、发展。
Objective:To study the levels of nitric oxide (NO) in serum of patients with nasopharyngeal carcinoma(NPC) and its clinical value.Method:The method of nitrifying ferment was used to test the level of NO and total concentration of NO - 3 and NO 2 from patients′ blood.Results:(1)The level of NO were higher in NPC patients than that in the healthy person.The former level was 111.16±39.41μmol/L, the latter was 68.64±17.36μmol/L (P<0.001);(2)After radiotherapy,the level of NO was lower; (3)The NO level in the lymph node metastasis group was lower than that in the non-metastasis group(P<0.05).Conclusion:The level of NO is higher in the nasopharyngeal carcinoma patients than that in the healthy person;in the course of nasopharyngeal squamous cell carcinoma,the composition and exhaust of NO are enhanced in the body of the patients.
出处
《山东大学基础医学院学报》
2004年第5期292-293,共2页
Journal of Preclinical Medicine College of Shandong Medical University
关键词
鼻咽肿瘤
一氧化氮
放射疗法
Nasopharyngeal neoplasms
Nitric oxide
Radiotherapy
