摘要
目的 探讨代谢紊乱患者脂联素水平、颈动脉粥样硬化的变化。方法 入选研究对象共 90例 ,根据代谢紊乱数目 ,分为无代谢紊乱组 (M0 )、1种代谢紊乱组 (M1)、2种代谢紊乱组(M2 )和 2种以上代谢紊乱组 (M3 )。评价了内皮依赖性舒张功能、颈总动脉内膜 中层厚度 (IMT) ,并测定了脂联素 (adiponectin)水平。 结果 M2 组和M3 组颈总动脉IMT分别高于M0 组和M1组(P <0 .0 5 )。M3 组颈总动脉斑块发生率高于M0 组 ,脂联素水平低于M1组 (P <0 .0 5 )。校正了影响因素后 ,M3 组脂联素仍与HOMA IR呈负相关。结论 代谢紊乱患者脂联素水平降低 。
Objective To investigate level of adiponectin and carotid atherosclerosis in subjects with metabolic disorder. Methods The endothelium-dependent relaxing function and carotid intima-media thickness(IMT) was detected and adiponectin were measured in 90 subjects. The subjects were divided into four groups: no metabolic disorder(M 0), one metabolic disorder(M 1), two metabolic disorders(M 2) and more than two metabolic disorders(M 3). Results M 2 and M3 groups had higher carotid IMT than M 1 or M0 groups(P<0.05). M 3 group had higher plaque occurrence rate than M 0 group and lower adiponectin levels compared with M 1 group(P<0.05). After adjustments for affecting factors in M 3, adiponectin levels were still negatively correlated with HOMA-IR. Conclusion The patients with metabolic disorder had lower adiponectin levels and accelerated the course of atherosclerosis.
出处
《临床内科杂志》
CAS
北大核心
2004年第10期684-686,共3页
Journal of Clinical Internal Medicine
