摘要
目的探讨先天性弓形虫感染与儿童患脑性瘫痪发生的关联性。方法 2 3 6例脑瘫患儿作为病例组 ,42 8例正常儿童作为对照组。将所有研究的病例按年龄分层为 4组 :～ 3月、～ 6月、～ 9月、～ 12月组 ,血弓形虫DNA(TOX DNA)、弓形虫循环抗原 (TOX CAG)、血弓形虫抗体IgM (TOX IgM )中 1项或 1项以上阳性 ,并排除其他的先天性感染疾病者确定诊断。 结果在～ 3月 ,～ 6月 ,～ 9月 3组儿童中 ,其相对危险度 (OR)与 95 %置信区间 (CI)分别为 :10 13、3 74— 2 7 42 ,7 71、2 45— 2 4 2 8,8 84、1 85— 42 3 1,均P <0 0 1。在～ 12月组中 ,OR =4 3 0 ,CI :0 83— 2 2 2 8,P >0 0 5。结论在病例组儿童中 ,存在弓形虫感染与脑瘫之间的关联性 ;检出弓形虫感染时年龄越小 。
ObjectiveTo investigate whether the Toxoplasma infection is the risk factor of occurrence of children cerebral palsy.Methods236 children with cerebral palsy and 428 normal children were included. Children were laminated to 4 groups by age: -3 months, -6 months, -9 months, -12 months. Final diagnosis was made by one or more finding following: plasma Toxoplasma DNA(TOX DNA), plasma Toxoplasma circulating antigen(TOX CAG), plasma Toxoplasma IgM(TOX IgM), exclusion other congenital infected diseases.ResultsThe OR and 95%CI were 10 13,3 74-27 42 in -3 months,7 71,2 45-24 28 in -6 months,8 84,1 85-42 31 in -9 months( P <0 01 respectively), and 4 30, 0 83-22 28( P > 05)in -12 months. ConclusionThere is correlation between the Toxoplasma infection and the children cerebral palsy; the earlier Toxoplasma infection, the greater the risk of cerebral palsy. Congenital Toxoplasma infection may be one of important factors in children cerebral palsy.
出处
《中国康复理论与实践》
CSCD
2004年第9期553-553,共1页
Chinese Journal of Rehabilitation Theory and Practice
关键词
弓形虫
脑性瘫痪
发生
儿童
Toxoplasma
cerebral palsy
occurrence
children
