摘要
皮肤是人体最大的器官组织,是机体与外界环境接触的屏障。具有保护、分泌、代谢和感觉等重要功能。当由于外界损伤或疾病等因素造成皮肤缺损时,可造成屏障功能丧失,可以造成感染、水电解质失衡、免疫低下、多脏器衰竭甚至是致命的。自1975年,Rheinwald和Green以3T3细胞作为滋养层连续培养人类表皮角阮细胞获得成功,为组织工程化皮肤提供了坚实的理论和实践基础。随后,胶原海绵、脱细胞基质以及自体或异体细胞复合皮肤产品或商品应运而生。近年来,干细胞研究、转基因技术又为组织工程增加了更强的生命力。本文对组织工程皮肤及其临床应用进展进行了综述。
The skin is the largest organ of human body, and it is body's important barrier to the outside environment. If the skin is injured or defected, the stability of internal enviroment of the body will be impacted and severe complications, such as infection, disorder of fluid and electrolytes, immunologic impairment, as well as mutiple organ failure, will occur. Since Rheinwald and Green (1975) established the culture method of the ker-atinocytes, tissue-engineered skin became approached. And then collagen membrane, acellular allodermis or composite artificial skin become successful merchandise in clinical use. In this article, the advances of tissue-engineered skin have been reviewed in culture of keratinocytes, dermal equivalent, composite skin, stem cells, gene transfection and their clinical applications.
出处
《国外医学（生物医学工程分册）》
2004年第5期274-277,共4页
Foreign Medical Sciences(Biomedical Engineering Fascicle)
关键词
组织工程
皮肤
临床应用
tissue engineering
skin
clinical applications
