摘要
目的 评价胰岛素泵连续皮下输注 (CSII)与静脉连续输注泵 (CVII)治疗糖尿病酮症酸中毒的疗效差异。方法 30例糖尿病酮症酸中毒患者分 2组 :(1)胰岛素泵连续皮下输注治疗 (CSII)组 15例 ;(2 )静脉连续输注泵治疗 (CVII)组 15例。结果 两组治疗后血糖均能明显下降 ,CSII组优于CVII组 ,差异有显著性 (P <0 0 1) ;CSII组平均胰岛素用量为 (0 6 7± 0 14 )U/ (kg·d)明显少于CVII组 (0 82±0 16 )U/ (kg·d) (P <0 0 5 ) ;CSII组尿酮体转阴时间为 (17 5± 7 4 )h明显短于CVII组 (4 1 2± 12 1)h(P <0 0 1) ;CSII组低血糖发生率为 (0 5 2± 0 2 2 )次 /人 ,显著低于CVII组的 (0 75± 0 2 6 )次 /人 ,(P <0 0 5 )。结论 CSII模拟胰岛素的生理分泌模式 ,能更快、更有效地纠正代谢紊乱 ,控制高血糖 ,明显改善生活质量。
Objective To evaluate the efficacy and safety of continuous subcutaneous insulin infusion(CSII)and continuous intravenous insulin infusion(CVII)with regular human insulin in patients with diabetic Retoacidosis.Methods 30 Diabetic ketoacidosis patients were randomized to receive either CSII by a portable insulin pump(n=15) or CVII(n=15).Results CSII and CVII were both effective in controlling blood glucose levels.CSII therapy provided better glycemic control(P<0.01).Mean insulin doses were significantly lower with CSII than with CVII[(0.67±0.14,U/(kg·d)vs(0.82±0.16)U/(kg·d),P<0.05];The time to correct ketonuria was shorter in CSII group compared with CVII group(17.5±7.4)vs(41.1±12.1)h,(P<0.01).The rate of hypoglycemia was reduced in CSII group than in CVII group (0.52±0.22) vs (0.75±0.26),(P<0.05).Conclusion CSII simulated pattern of insulin secretion is effective in treating ketoacidosis and hyperglycemia.It can rapidly improve metabolic control and enable a better quality of life.
出处
《中华急诊医学杂志》
CAS
CSCD
2004年第5期331-333,共3页
Chinese Journal of Emergency Medicine
