载体介导的哺乳动物细胞RNA干扰技术与基因治疗
RNA Interference Mediated by Vector System and Gene Therapy in Mammalian Cells
摘要
RNA干扰(RNA interference,RNAi)是生物在进化过程中,抵御病毒感染及由重复序列和突变引起基因组不稳定 性的保护机制。RNAi是由双链RNA引发的靶基因mRNA降解而导致基因转录后沉默的现象,研究者利用这一现象对要研 究的基因进行抑制,从而形成了RNAi技术。RNAi具有特异高效的特点,因此该技术已在研究基因功能和进行基因治疗中得 到广泛应用。RNAi的实现途径有多种,每种方式都各有优缺点。
出处
《中国肿瘤生物治疗杂志》
CAS
CSCD
2004年第3期223-225,共3页
Chinese Journal of Cancer Biotherapy
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