摘要
在Ｗｉｓｔａｒ大鼠肝左叶被膜下接种Ｗａｌｋｅｒ－２５６系肝癌组织６天后，将５－氟尿嘧啶硅橡胶囊控释植入剂（５－ＦｕＣＩ）植入肿瘤所在的肝左叶，观察其抑瘤率及带瘤大鼠生存时间，并与对照组及５－ＦｕＣＩ放置于肝右叶组相比较。结果表明：３组动物３０天生存率分别为１００％、３３．３％及５０％。实验组动物抑瘤率为９６．３％，且动物生存时间较其它两组明显延长（Ｐ＜０．０５），光镜下可见大量癌细胞坏死。
Controlled-release implant 5-Fluorouracil (5-FuCI) made of silastic elastomer is 2mm in outer diameter and 25 mm in length. The daily delivery dose of 5-Fu is approximately 30 μg in vitro. This study investigated its antineoplastic effect. 6 dogs after carcinosarcoma implantation, 5-FuCI were implanted in left lobe of liver (group C),right lobe (group D) and control group. The results revealed: 30 days survival rates of three groups were 100%, 50% and 33.3% respectively. Group C had significantly longer survival time than that of group D and control group. A number of focal necrosises in cancer tissue were found under light microscope in group C.
