摘要
目的 研究CD44V6、PCNA在胃癌中表达相互关系及其生物学特征。方法 采用免疫组织化学方法(S-P法)。检测53例胃癌组织CD44V6、PCNA的表达情况。20例正常胃粘膜组织作对照。结果 53例胃癌组织中CD44 V6阳性表达率62.3％(33/53);PCMA阳性表达率92.5％(49/53),其中强阻性表达率64.2％(34/53);CD44V6阳性率和PCNA强阳性表灰率与胃癌组织学类型、侵润深度、淋巴结转移均呈正相关(P<0.05)。结论 联合检测CD44V6、PCNA在胃癌中的表达对判断胃癌的生物学行为及估计预后具有重要价值。
Objective To study the expression and biological characters of CD44V6 and PCNA in gastric cancer. Methods The expression of CD44 V6 and PCNA was detected in 53 cases of gastric cancer by streptavidin peroxidase immunohistochemistry technique. They were compared with the other 20 cases of normal gastric mucosa. Results In 53 cases of gastric cancer, the positive expression rate of CD44 V6 was 62.3 % (33/ 53). And of PCNA the positive rate was 92.5% (49/53), the strong positive rate was 64.2% (34/53); The positive rate of CD44V6 and the strong positive rate of PCNA were correlated with histological types, depth of invasion and lymph node metastasis of gastric cancer (P < 0.05) . Conclusion The combination detection of CD44V6 and PCNA is of important value to evaluating biological behavior of gastric cancer and the prognosis of the patients in gastric cancer.
出处
《实用肿瘤学杂志》
CAS
2004年第5期325-327,共3页
Practical Oncology Journal
