摘要
目的 :研究血浆凝血因子Ⅰ (Fg)和血脂水平对冠状动脉病变严重程度的影响。方法 :对 94例冠心病患者进行了冠状动脉造影检查 ,管腔狭窄程度≥ 5 0 %认为是有意义的病变血管 ,两支及以上血管病变认为是多支血管病变。血浆Fg浓度测定采用Follin酚法 ,采用标准酶法测定血清总胆固醇 (TC)、三酰甘油 (TG)及高密度脂蛋白胆固醇 (HDL C)水平 ,采用免疫比浊法测定载脂蛋白 (apo)A和apoB。 结果 :多支血管病变患者血浆Fg浓度增高 ,同时表现TC、TG亦升高 ,HDL C降低 ,而且发现冠状动脉病变严重程度与血浆Fg浓度间存在显著正相关 (r =0 .37,P <0 .0 1) ,与血清HDL C之间存在显著负相关 (r =- 0 .33,P <0 .0 1)。结论 :血浆Fg和血脂水平对冠状动脉病变严重程度有不同程度的影响。
Objective:To determine whether plasma fibrinogen levels and blood lipid are related to coronary narrowing. Method:Coronary angiography were performed in 94 patients with coronary heart disease, coronary narrowing >50% was significant. plasma fibrinogen levels and blood lipid were simultaneously measured in 94 patients with coronary heart disease. plasma fibrinogen concentrations (g/L) were assayed by Follin phenol method.Total cholesterol (TC), triglyceride (TG) and high density lipoproteion (HDL-C) levels were assayed by standard enzyme method. Apolipoproteion(apo)A1 and apoB were assayed by immunoassay. Result:Plasma fibrinogen levels increased in the same as the raise of TC,TG and a reduction of HDL-C.A significant negative correlation (r=- 0.33, P< 0.01) was found between HDL-C and coronary narrowing, A significant passitive correlation (r= 0.37,P< 0.01) was found between plasma fibrinogen levels and coronary narrowing in the patients with coronary heart disease.Conclusion:Blood lipid and plasma fibrinogen levels inffluence coronary narrowingcertainly in patients with coronary heart disease.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2004年第10期579-580,共2页
Journal of Clinical Cardiology
