摘要
目的 :研究不同甲状腺功能状态 (甲亢、甲减及正常 )神经肽Y的水平。方法 :选取甲亢患者 5 5例 ,甲减患者 4 7例和正常对照 5 7例 ,放射免疫分析其NPY水平。结果 :甲亢患者 (无论性别 )NPY水平 (71 5±14 7)ng/L较正常对照组 (5 2 3± 11 8)ng/L呈显著性增高 (0 0 0 1<P <0 0 5 ) ;甲减组NPY水平 (4 2 2±2 4 3)ng/L较正常对照组 (5 2 3± 11 8)ng/L低 ,但无显著性差异 (P >0 0 5 ) ;甲亢组 (71 5± 14 7)ng/L较甲减组 (4 2 2± 2 4 3)ng/L呈显著性增高 (P <0 0 0 1) ;所有样本NPY与瘦素 (Leptin)关系分析呈负相关 (r =-0 5 8,P =0 .0 15 )。结论 :甲状腺激素与NPY是影响人体正常能量代谢的激素 ;甲状腺激素与NPY可能存在相互影响的关系。
Objective To investigate the plasma neuropepride Y levels in patients with different thyroid functional status(hypo, hyperthyroidism as well as euthyroid status). Methods Plasma neuropeptide Y levels in 55 hyperthyroid patients, 47 hypothyroid patients and 57 euthyroid controls were measured with radioimmunoassay. Results Plasma neuropeptide Y levels in hyperthyroid patients (71.5±14.7)ng/L, were significantly higher than those in controls (71.5±14.7)ng/L, (0.001<P<0.05). Plasma neuropeptide Y levels in hypothyroid patients (42.2±24.3)ng/L were lower than those in controls (71.5±14.7)ng/L, were significantly higher than those in hypothyroid patients (42.2±24.3)ng/L; Plasma neuropeptide Y levels were negatively correlated with leptin levels in all samples (r=-0.58, P=0.015). Conclusion Both neuroppepride Y and thyroid hormones were important factors of energy metabolism and they might work together to maintain encrgy balance.
出处
《放射免疫学杂志》
CAS
2004年第5期348-350,共3页
Journal of Radioimmanology
