摘要
目的 :探讨人类白细胞抗原 (HLA)群体反应性抗体 (PRA)对肾移植效果的影响。方法 :采用酶联免疫吸附法 (ELISA)对 2 0 6例肾移植受者的血清PRA进行检测。同时对 14 0份血清分成四组包括首次移植术前及术后 1个月 ,半年至 1年肾功能稳定期病人 ,第一次尸肾移植失功恢复血透病人进行PRA检测。结果 :PRA阴性组受者移植术后排斥发生率为 11 85 % ,阳性组受者平均PRA高达 4 6 5 % ,两组比较差异显著 (P <0 0 0 1)。首次移植术前A组PRA阳性率 17 1% ,术后B组PRA阳性率 31 4 % ,肾功能稳定组 (C组 )PRA阳性率 14 3%。而移植失功恢复血透者 (D组 )PRA阳性率达 77 1%。结论 :PRA的检测是肾脏移植术前筛选致敏受者的重要指标 ,对肾脏移植后排斥反应和移植物存活率关系密切。
Objective To investigate the effect of the presence of population reactive antibody (PRA) on the outcome of renal allografts. Methods Serum PRA positive rate was tested with ELISA in 206 patients receiving kidney transplantation. Dynamic detection of PRA levels were carried out in 4 more groups of patients (n=35 in each group) at ① before surgery ② 1 month after operation ③ 6 months to 1 year after transplantation with stable and satisfactory renal function ④ after rejection of the grafte and patients on maintainence hemaodialysis again. Results In the 206 patients receiving kidney transplantation, the rejection reaction rate was only 12.3% in the 135 PRA negative patients. mean rejection reaction rate in the 71 patients with PRA above 10% was 46.5% (P<0.001). In the four 35-patients groups, PRA positive rate was as high as 77.1% in the group with the allograft rejected, the mean PRA positive rate was only around 20% in the other three groups tested. Conclusion PRA is an important indicator of possible sensitization to a graft and is closely related to the success or failure of the transplantation operation.
出处
《放射免疫学杂志》
CAS
2004年第5期393-394,共2页
Journal of Radioimmanology
