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造血干细胞移植后嵌合状态的检测及定量研究进展

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摘要 异基因造血干细胞移植后嵌合状态的形式有三种:完全供者嵌和状态、混合嵌和状态及完全受者型。微卫星DNA等分子学检测嵌和状态的方法都是利用人类基因组中具有高度多态性的DNA遗传标记来区分个体。定量检测嵌合状态的方法有:凝胶成像密度扫描、DNA测序仪和基因扫描软件程序、多重PCR扩增微卫星标志、高效液相色谱及实时定量PCR等。
作者 石慧文 朱平
机构地区 北京医科大学附属北京儿童医院血液病中心
出处 《国外医学（输血及血液学分册）》 2004年第5期395-398,共4页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
关键词 嵌合状态 异基因造血干细胞移植 供者 实时定量PCR 微卫星标志 分子学 定量检测 人类基因组 DNA遗传标记 DNA测序
分类号 R446.9 [医药卫生—诊断学]
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参考文献38

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共引文献28

国外医学（输血及血液学分册）
2004年 第5期

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