摘要
目的 :观察嘿良冲剂高、中、低剂量在实验 4d、 8d、 12d、 16d对环磷酰胺 (CTX)所致小鼠白细胞总数 (WBC)、中性粒细胞 (N)减少的影响。方法 :每天腹腔注射CTX 10 0mg/kg ,连续 3天 ,诱发小鼠白细胞总数 (WBC)、中性粒细胞 (N)下降 ,在给予CTX的同时 ,应用不同剂量的嘿良冲剂进行治疗 ,动态观察嘿良冲剂对白细胞总数 (WBC)、中性粒细胞 (N)下降的影响。结果 :实验 4d ,嘿良冲剂各剂量组的WBC、N值与CTX模型组比较无明显变化 (P >0 0 5 ) ,实验 8d ,嘿良冲剂高、中剂量组的WBC值升高 (P <0 0 5 ) ,高、中、低剂量组N值升高 (P <0 0 1) ,实验 12d ,嘿良冲剂各剂量组的WBC、N值与CTX模型组比较明显升高 (P <0 0 1) ,实验 16d ,嘿良冲剂各剂量组、CTX模型组的WBC、N值回升 ,各组间比较差异无显著性意义 (P >0 0 5 )。结论 :实验 8d、实验 12d ,嘿良冲剂对环磷酰胺 (CTX)所致小鼠白细胞总数 (WBC)、中性粒细胞 (N)
bjective:To investigate the protective action of HLCJ on the leukopenia and neutropenia induced by cytoxan(CTX)in mice. Method: Models of mice with leukopenia and neutropenia here were made by injecting with CTX(100 mg/kg)for 3 days,meanwhile,these mice were treated with HLCJ and the dynamic changes of 1eukocyte and neutrophil in these mice were observed.Results:HLCJ(32g/kg,16g/kg) administrated for 8 days could improve leukopenia and neutropenia induced by CTX in mice.Oral administration of HLCJ (32g/kg,16g/kg,8g/kg) for l2 days could increase the decreased number 0f 1eukocytes and neutrophil in CTX treated mice. Conclusion: HlCJ has significant protective effect on leukopenia and neutropenia induced by cytoxan in mice.
出处
《中国民族民间医药》
2004年第5期295-297,共3页
Chinese Journal of Ethnomedicine and Ethnopharmacy
