摘要
目的 研究和评价L 谷氨酰胺对慢性呼吸衰竭合并营养不良患者免疫功能的影响。方法 对 32例慢性呼吸衰竭患者进行营养支持治疗 ,总能量摄入为静息能量消耗 (REE)的 1.5倍。A组 (14例 )为L 谷氨酰胺治疗组 ,每日 3次口服L 谷氨酰胺 10 g,B组 (18例 )为营养对照组。结果 营养支持后 ,A组肱三头肌皮褶厚度和前白蛋白等营养参数较B组改善明显 (P <0 .0 5 )。A组治疗后α 肿瘤坏死因子和CD8显著下降 ,白介素 2、一氧化氮、IgG、CD3、CD4和CD4 /CD8显著上升 ,并明显高于B组治疗后。结论 L 谷氨酰胺对慢性呼吸衰竭营养不良患者不仅有辅助营养支持作用 ,并具有免疫增强和调理作用 ,达到强化营养支持的效果 ,从而改善预后 。
Objective To evaluate the effect of glutamine on immune function in malnourished patients with chronic respiratory failure.Methods 32 patients were randomly divided into 2 groups: 14 patients in group A and 18 patients in group B. The total calorie intake was 1.5- folds of the resting energy expenditure (REE) with group A received L-glutamine 10 g tid and group B served as control.Results In contrast to group B, the nutritional parameters such as TSF(triceps skinfolds), PALB (pre-albumin) were improved, the TNF-α, CD8 decreased and IL-2, NO, CD3, CD4, CD4/ CD8 increased significantly in group A.Conclusion L-glutamine is not only effective as nutritional support in chronic respiratory failure, but also improves patients' immune function significantly. It can improve the prognosis and thus of good practical value in clinical practice.
出处
《上海医学》
CAS
CSCD
北大核心
2004年第9期646-648,共3页
Shanghai Medical Journal
基金
上海市高等学校科学技术发展基金资助项目( 2 0 0 0B0 9)
