摘要
目的 :从银杏外种皮中得到银杏酸混合物及三种单体 ,研究银杏酸的抗菌活性及其侧链与活性的关系。方法 :采用二倍稀释法测定了银杏酸混合物、各单体及水杨酸的最低抑菌浓度。结果 :银杏酸混合物对痤疮丙酸杆菌等G+菌具有良好的抑制作用。水杨酸无侧链 ,无抗菌活性。银杏酸侧链为C13∶0时抑菌效果最强。结论 :银杏酸的侧链是其产生抗菌活性的主要效应部位 。
Objective: Ginkgolic acids and their three monomers were separated from ginkgo sarcotestas The anti bacterium activity of ginkgolic acids were tested The relation between the anti bacterium activity and side chain of ginkgolic acid were studied Method: The MIC of ginkgolic acids and their three monomers and salicylic acid were tested Results: Ginkgolic acid has strong inhibitive effect on G + bacterium Salicylic acid has no side chain, so no anti bacterical activity. When the length of gingkolic acid side chain is C13∶0, it has the strongest anti bacterical activity in three monomers Conclusion: The side chain of ginkgolic acid is the key functional group that possessed anti bacterical activity The length of Ginkgolic acid was the main effective factor of anti bacterical activity
出处
《中药材》
CAS
CSCD
北大核心
2004年第9期661-663,共3页
Journal of Chinese Medicinal Materials
基金
江苏省教育厅自然科学研究项目 (0 1KJD3 10 0 0 3 )
