摘要
采用大鼠心肌缺血再灌注模型 ,观察槲皮素对缺血再灌注心肌损伤的保护作用。实验大鼠分为假手术组、缺血再灌注组、槲皮素组和维拉帕米组。观察槲皮素对各组大鼠血清肌酸磷酸激酶 (CPK)、谷胱甘肽过氧化物酶(GSH Px)以及ATP酶的影响 ,并通过光镜及电镜观察病理学改变。结果表明 :槲皮素可显著降低CPK活性 ,升高GSH Px和ATP酶活性。提示 :槲皮素对缺血再灌注心肌具有保护作用 ,病理结果进一步证实了这一点。推测其机制可能与抗脂质过氧化反应及增强心肌的能量代谢。
Protective effects of quercetin on myocardium ischemia repurfusion injury were studied in rats. Wistar rats were divided into 6 groups: pseudo operation; ischemia reperfusion operation; ischemia reperfusion with quercetin 0.2 mg/kg, 1.0 mg/kg and 5.0 mg/kg; ischemia reperfusion with verapamil 1 mg/kg. The results showed that quercetin possesses protective effects on myocardium ischemia reperfusion injury in rats and its mechanism may be related to inhibition of lipid peroxidation of quercetin.
出处
《首都医科大学学报》
CAS
2004年第3期311-313,共3页
Journal of Capital Medical University
