摘要
目的 :探讨应用中药肺积方与化疗结合治疗晚期非小细胞肺癌的疗效和应用价值。方法 :将 5 4例晚期非小细胞肺癌患者随机分为两组 ,A组 2 6例给予中药肺积方与化疗结合治疗 ,B组 2 8例以常规单纯化疗治疗 ,观察治疗前后肿瘤控制疗效 ,患者肿瘤坏死因子 -α(TNF -α) ,对比化疗结束 (第 8天 )和疗程结束 (第 2 1天 )体能状态卡氏 (KPS)评分和外周血白细胞总数变化。结果 :A组治疗后肿瘤控制 (CR +PR)有效率为 34.6 % ,B组有效率为 2 8.6 % ,两组对比无显著差异 (P >0 .0 5 )。A组治疗后比治疗前肿瘤坏死因子 -α下降率为 5 7.7% ,疗程结束后 (第 2 1天 )比化疗用药结束后 (第 8天 )体能状态卡氏评分上升率为 5 3.8% ,外周血白细胞总数上升率为 5 7.7% ,B组则分别为 2 8.6 % ,2 1.4 % ,17.9% ,两组对比有显著差异 (P <0 .0 5 )。结论 :中药肺积方与化疗结合治疗晚期非小细胞肺癌 ,其肿瘤缓解率与单纯化疗相当 ,但其对改善化疗后患者生存质量 。
Objective: To probe the therapeutic effect and practical value of Feiji Fang combined with Chemotherapy in treating non-microcytic lung cancer of later stage. Method: Fifty-four cases of Non-microcytic lung cancer of later stage were randomly divided into two groups. Group A (26 cases) were treated by Chinese drug Feiji Fang combined with chemotherapy. Group B (28 cases) were treated only by chemotherapy. The tumor control therapeutic effect, tumor necrotic factors-α(TNF-α) were observed respectively before and after the treatment to compare Kveim of Physical State (KPS) grading and the change of total quantity of outside blood white cells at the end of chemotherapy (the eighth day) and treatment course. Results: In the effective rate of tumor control (CR+PR), there was no obvious difference between Group A (34.6%) and group B (28.6%). Compared with the pretreatment, tumor necrotic factors-α(TNF-α) of Group A decreased 57.7% after the treatment. Compared with the end of chemotherapy (the 8th day), kveim of physical state (KPS) grading increased 53.8% at the end of treatment course, the quantity of outside white blood cell increased 57.7%. While the Group B got 28.6%, 21.4%, 17.9% respectively. It showed that two groups had a great difference. Conclusion: The Chinese drug Feiji Fang Combined with chemotherapy in treating Non-microcytic lung cancer of later stage has an equivelent remission rate with the single chemotherapy, but it has a much better therapeutic effect in improving the patient's life quality and relieving the toxic and side effect after the chemotherapy.
出处
《河南中医》
2004年第10期23-25,共3页
Henan Traditional Chinese Medicine
