摘要
目的:比较米安色林与米帕明对抑郁症患者社会功能的影响。方法:将符合中国精神疾病分类与诊断标准第3版中关于抑郁症诊断标准的患者100例,随机分为米安色林组(n=50)和米帕明组(n=50),分别服用米安色林和米帕明,初始剂量分别为30和75mg/d,3d内将剂量分别增加到60和150mg/d,再根据病情增减剂量;用社会功能缺陷量表(SDSS)、汉密顿抑郁量表(HAMD)、副反应量表(TESS)评定;并进行多元逐步回归分析。结果:两组间治疗前及治疗后各阶段HAMD评分比较,差异均无显著性(t=0.07～0.54,P均>0.05);治疗后各阶段与同组治疗前比较,差异均有非常显著性(t=2.72～2.89,P均<0.01)。两组治疗后SDSS评分与治疗前比较,差异均有显著性(t=2.82～2.91,P均<0.01);米帕明组治疗后第10和第12个月SDSS评分均高于米安色林组,差异有显著性(t=2.29,2.24,P均<0.05)。多元逐步回归分析显示,影响社会功能的因素为药物类型、伴精神病性症状、家庭社会支持、发作次数(t=-3.178,2.863,2.563,-2.346,P均<0.05～0.01)。结论:抑郁症患者社会功能的改善与症状不一致,米安色林比米帕明能较好地改善抑郁症患者社会功能,更有利于患者适应社会。
AIM:To compare the social function of patients with depression treated with mianserine or imipramine. METHODS:A total of 100 depressive patients,who were in accordance with the third edition of the Chinese Classification and Diagnostic Criteria of Mental Disorders(CCMD 3),were randomly assigned into mianserine group(n=50) and imipramine group(n=50).The patients were treated with mianserine and imipramine respectively,the initial 30 and 75 mg per day,and added to 60 and 150 mg per day respectively within three days,and then the doses were added or reduced according to the condition of the patients.All the patients were evaluated with the social disability screening schedule(SDSS),Hamilton depressive scale(HAMD) and the treatment emergent symptom scale(TESS),and then the data were analyzed with multiple stepwise regression. RESULTS:There were no significant differences in the HAMD scores before and at different stages after treatment between the two groups(t=0.07 to 0.54,P >0.05), and there were very significant differences before and at different stages after treatment in both groups(t=2.72 to 2.89, P< 0.01). The scores of SDSS after treatment were significantly different from those before treatment in both groups (t=2.82 to 2.91,P< 0.01).The scores of SDSS 10 and 12 months after treatment in the imipramine group were significantly higher than those in the mianserine group(t=2.29, 2.24,P< 0.05).The results of multiple regression analysis showed that the main factors which affected the impaired social function were the type of medicine,psychotic symptoms,social family support system and episode times(t=-3.178,2.863,2.563,-2.346,P< 0.05 to 0.01). CONCLUSION:The improvement of social function is discrepant with the symptoms in patients with depression.Compared with imipramine,mianserine can improve the social function in depressive patients more effectively,and it is better for the patients to be fit to the society.
出处
《中国临床康复》
CSCD
2004年第30期6588-6590,共3页
Chinese Journal of Clinical Rehabilitation
