摘要
目的 探讨婴幼儿反复呼吸道感染 (recurrentrespiratorytractinfection ,RRI)的发病因素 ,为积极预防及早期免疫调理治疗RRI找出一条新的有效途径。方法 抽取 111例正常出生的新生儿脐血 ,检测白细胞介素 12 (IL 12 )等细胞因子水平作为脐血组 ;随后进行追踪随访观察 ,于 18个月时再次抽取静脉血 ,检测IL 12及其他细胞因子水平 ,其中有 18例符合反复呼吸道感染的诊断标准 ,作为RRI组 ,其余为健康组。分别对脐血健康组、脐血RRI组、18个月健康组、18个月RRI组进行比较。结果 RRI组血清IL 12、IFN γ、IL 2细胞因子水平均低于健康组 (P <0 0 0 1)。结论 反复呼吸道感染患儿除一些外在的发病诱因外 ,其自身先天免疫功能低下 。
Objective To explore the pathogenic factors of recurrent respiratory tract infection(RRI)so as to find out an effective way of preventing and treating the disease.Methods In 111 cases of new-born babies with normal birth,the cord blood was with drawn and a follow-up survey was made on then.After a period of 18 months,the venous blood of the babies was again withdrawn,with 18 cases diagnosed of RRI.The levels of IL-12?IFN-γ?IL-2?IL-6?and IL-8 in the venous blood(18?months)and the cord blood were detected respectively.Results In comparison there were noticeable differences levels of IL-12?IFN-γ and IL-2(P<0.001)in between the health cord group and the health group(P<0.001).Conclusion The babies with recurrent respiratory tract infection showed a lower immune function besides some external predisposing facators and especially the lower cellular immune functon in them was the important internal cause of the diseases onset.
出处
《小儿急救医学》
2004年第5期308-310,共3页
Pediatric Emergency Medicine
