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急性冠状动脉综合征与C反应蛋白关系探讨

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摘要 目的 探讨急性冠状动脉综合征患者血清C反应蛋白 (CRP)水平变化及临床意义。方法 选择 2 2例ST段抬高型心肌梗死 (STEMI)患者、18例非ST段抬高型心肌梗死 (NSTEMI)患者、30例不稳定型心绞痛 (UAP)患者、38例稳定型心绞痛 (SAP)患者和 2 6名健康体格检查者为研究对象 ,用速率散射比浊法检测血清CRP水平 ,比较各组入院时及治疗 3个月后CRP水平变化情况。结果 STEMI组、NSTEMI组、UAP组入院时CRP水平 ((6 9± 2 0 )mg/L ,(4 6± 13)mg/L ,(2 3± 8)mg/L)明显高于SAP组 ((4 .8± 1.8)mg/L)和对照组 ((3.7± 1.5 )mg/L) ,P均 <0 .0 1,STEMI组与NSTEMI组比较、NSTEMI组与UAP组比较差异均有统计学意义 (P <0 .0 5 )。STEMI组、NSTEMI组、UAP组入院时CRP水平与治疗 3个月后 ((33± 10 )mg/L ,(2 0± 8)mg/L ,(11± 6 )mg/L)比较 ,差异均有统计学意义(P <0 .0 1)。SAP组入院时及治疗 3个月后 ((4 .7± 1.6 )mg/L)与对照组比较无统计学意义 (P >0 .0 5 )。结论 急性冠状动脉综合征患者CRP水平显著升高 ,提示炎症反应在急性冠状动脉综合征发生、发展中起重要作用 ,CRP是冠心病患者发生急性冠状动脉综合征的独立预测因子 。
作者 刘君 徐曙东
出处 《现代中西医结合杂志》 CAS 2004年第21期2828-2829,共2页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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