期刊文献+

组织工程化口腔黏膜载体材料聚乳酸羟基乙酸膜的制作及物理特性 被引量:7

Preparation and Properties of PLGA Membrane for Oral Tissue-engineered Mucosa
下载PDF
导出
摘要 目的 制作组织工程化口腔黏膜载体材料,研究其物理特性。方法 不同比例的聚乳酸(PLA)和聚乙醇酸(PLG)按常规成膜技术制备聚乳酸羟基乙酸(PLGA)。测定其孔隙率,倒置相差显微镜和电子扫描显微镜(SEM)观察其物理特性。结果 PIGAⅠ、Ⅱ、Ⅲ为平滑透明膜,孔隙率10.56%、18.24%、8.64%,SEM观察呈现数目不等微孔和纤维交织样结构;PIGAⅠV及改性膜不透明,较脆,孔隙率为56.39%左右,SEM观察为泡孔网海绵状。结论 PLGA Ⅰ、Ⅱ、Ⅲ具较好的透明度及孔隙率,可被用作组织工程化口腔黏膜载体材料。 Objective To construct polycledeclide-co - plycolide(PLGA)membranes and study their physical properties. Methods A series of PLGA membranes were constructed with different proportions of poly- L- Lactic acid and polyglycolic acid,and the porous rates and physical properties of PLGA were studied. Results PLGA Ⅰ, Ⅱ , Ⅲ were transparent membranes with porous structure, and their porous rates were 10.56% , 18.24% , 8.64% .respectively;PLGA Ⅳ and other membranes were fragile and not transparent membranes with spongy structure, and porous rates was 56.39% . Conclusion PLGA membranes we made were ideal materials for oral tissue - engineered mucosa due to their good physical properties.
出处 《口腔医学》 CAS 2004年第5期297-299,共3页 Stomatology
关键词 聚乳酸羟基乙酸 孔隙率 支架 组织工程化口腔黏膜 Polycledeclide-co-plycolide Porous rate Scatford Oral tissue engineered mucosa
  • 相关文献

参考文献11

  • 1Kim BS, Mooney DJ. Development of biocompatible synthetic extracellular matrices for tissue engineering [J]. Trends Biotechnol, 1998,16(5) :224 - 230.
  • 2Dietmar WH. Scaffold in tissue engineering bone and cartilage[J].Biomaterials, 2000,21(24) :2529 - 2543.
  • 3Freed CE, Vunjak-novakovic G, Iron KJ. Biodegradable polymer scaffolds for tissue engineering [J]. Biotechnology NY, 1994,12(7) :689- 693.
  • 4Grands DA, Halborstadt C, Naughton G, et al. Evaluation of matrx scaffolds for tissue engineering of articular cartilage grafts [ J ] . J Biomed Mater Res, 1997,34(2) :211 - 220.
  • 5Solchaga LA, Dennis JE, Golldberg VM, et al. Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage [J]. J Biomed Meter Res, 1999,17(2):205-213.
  • 6Temenoff JS, Mikos AG. Review tissue engineering for regeneration of articular cartilage [J]. Biomaterials, 2000,21(5) :431 - 440.
  • 7Solchaga LA, Dennis JE, Goldberg VM, et al. Hyaluronic acidbased polymers as cell carriers for tissue-engineered repair of bone and cartilage [J]. Journal of Orthopaedic Research, 1999,17(2):205-231.
  • 8Temenoff JS, Mikos AG. Review: Tissue engineering for regeneration of articular carrtilage [ J ]. Biomaterials, 2000,21 (5): 431 - 440.
  • 9Amaldo R, Samuel H, Eliana Aparecida R, et al. Veto cell growth and differentiation on poly(L-Lactic acid) membranes of different pore diameters[J]. Artif Organs, 2001,25(1) :7 - 13.
  • 10Nam YS, Park TG. Porous biodegradable polymeric scaffolds prepared by thermally phase separation[ J ]. J Biomed Mater Res, 1999,47( 1 ):8- 17.

同被引文献77

引证文献7

二级引证文献42

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部