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长效干扰素的相关不良反应 被引量:13

Adverse reactions related to pegylated interferons
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摘要 本文对长效干扰素治疗慢性丙型肝炎中出现少见和严重的不良反应进行综合报道,包括少见的皮肤损害、严重的肺部损害和精神神经系统不良反应等,旨在提醒临床医生使用长效干扰素时应注意类似不良反应的发生,保证患者用药安全。
作者 马秀云
机构地区 北京地坛医院
出处 《药物不良反应杂志》 2004年第5期312-315,共4页 Adverse Drug Reactions Journal
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参考文献16

  • 1Jessner W, Kinaciyan T, Formann E, et al. Severeskin reactions during therapy for chronic hepatitis C associated with delayed hypersensitivity to pegylated interferons [J] .Hepatology, 2002, 36 (4): 361.
  • 2Gomez Rangel JD, Ruiz Delgado GJ, Ruiz Arguelles GJ. Pegylated-interferon induced severe bone marrow hypoplasia in a patient with multiple myeloma receiving thalidomide [J] . Am J Hematol, 2003, 74(4): 290.
  • 3Thorne J, KnopfU. Acute psychosis after injection of pegylated interferon alpha-2a [ J] . Eur Psychiatry,2003, 18 (3): 142.
  • 4WendlingJ, DescampsV, GrossinM, etal. Sarcoidosis during combined interferon alfa and ribavirin therapy in 2 patients with chronic hepattis C [J] . Arch Dermatol, 2002, 138 (5): 546.
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  • 6Golstein PE, Delforge ML, Deviere J, et al. Reversible myopathy during successful treatment with pegylated interferon andribavirin for acute hepatitis C[J].JViralHepat, 2004, 11(2): 183.
  • 7Primo Vera J. Pegylated interferon-induced diabetes mellitus type 1 in two patients with chronic hepatitis C[J]. GastroenterolHepatol, 2004, 27(2): 69.
  • 8Thomas WL Jr, Ramos F, Hospenthal DR. Adverse response to pegylated interferon therapy in two patients with chronic hepatitis C [ J] . Hawaii Med J, 2003,62(8): 163.
  • 9KurzenH, PetzoldtD, HartschuhW, etal. Cutaneous necrosis after subcutaneous injection of polyethyleneglycol- modified interferon alpha [ J] . Acta Derm Venereol, 2002, 82 (4): 310.
  • 10GallelliL, GuadagninoV, CaroleoB, etal. Bilateral skin ulceration after injection of pegylated interferon-alpha-2b in a patient with chronic hepatitis C [ J] . Clin DrugInvest, 2003, 23 (6): 615.

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