摘要
目的 应用ROC曲线定量分析肌钙蛋白Ⅰ (cTnI)以探讨CtnI对心肌梗死的诊断价值。方法 酶联荧光分析法测定病例组与健康对照组的血清cTnI ,对cTnI进行统计学比较 (t检验 )和ROC分析。结果 cTnI在心肌梗死诊断中的ROC曲线图左上方最高点为 0 6 μg/L ,敏感性为 88% ,特异性 97% ,阳性结果预测值为 95 % ,准确度为 93%。cTnI的AUC =0 96 2。结论 cTnI在AMI诊断中的最佳临界值为 0 6 μg/L ,比生产厂商提供的诊断临界值 0 8μg/L低 ,故生产厂商提供的诊断临界值只能作为参考 ,各临床实验室应根据各自的方法学 。
Objective To analyze quantitatively the cardiac tropinin (cTnI) in the diagnosis of myocardial infarction (MI) by using the receiver operating character curve (ROC). Methods Detecting the cTnI in MI patients and in control group by Enzyme-linked Fluorescent Assay (ELFA) technique,then analyzing the data with t-test and ROC curve. Results At the peak point of the ROC curve the cTnI was 0.60 μg/L in MI,which generated diagnostic sensitivity of 88%,specificity of 97%,positive predictive value of 95%,accuracy of 93% and the area under curve (AUC) of 0.962. Conclusion The best diagnostic cut-off point of cTnI in our laboratory is 0.6 μg/L,which is lower than the cut-off point 0.8 μg/L of manufacturer.So each laboratory should decide their own cut-off points in the diagnosis of MI which adapted to their own methods.
出处
《广州医药》
2004年第6期28-30,共3页
Guangzhou Medical Journal
