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药物涂层支架的研究进展 被引量：4

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摘要 药物涂附支架解决了抑制血管成形术后再狭窄靶部位有效药物浓度和药物作用时间问题 ,具有代表性的药物涂附支架包括雷帕霉素支架、Taxol支架和肝素涂层支架 ,以及一氧化氮及其衍生物涂层支架和水蛭素涂层支架等。雷帕霉素支架和Taxol支架的动物和临床研究获得了较好实验结果。药物涂层支架防治再狭窄的长期效果尚需通过严格设计的动物实验和随机、双盲、安慰剂对照的大规模临床研究才能作出客观评价。
作者 李慧丽 万锕俊 王彬尧 黄定九
机构地区 上海第二医科大学附属仁济医院心内科 上海交通大学化学系
出处 《心脏杂志》 CAS 2004年第5期476-479,共4页 Chinese Heart Journal
关键词 涂层支架 药物 再狭窄
分类号 R543.3 [医药卫生—心血管疾病]
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参考文献24

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同被引文献35

  • 1张莉莉,贾国良,王海昌,郭文怡,马兰香,孙玉波.抗血小板药物对冠心病支架植入术后再狭窄防治效果的观察[J].心脏杂志,2004,16(5):459-461. 被引量：9
  • 2Weaver WD, Simes R J, Ellis SG, et al. Comparison of primary coronary angiophlasty and intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review [ J ] .JAMA, 1997.228:2093.
  • 3Stone GW,Grines BR, rothboaum D, et al. Analysis of the relativecosts and effectiveness of primary angioplastic bersus tissue - type plasminogen actibator: the primary angioplasty in myocardial infarction(PAMI) Trial[J] .JAM Coll Cardiol. 1997,29:901.
  • 4Braunwald 陈灏珠主译.心脏病学[M](第5版)[M].北京:人民卫生出版社,2001.1237-1247.
  • 5Grech ED.ABC of interventional cardiology:percutaneous coronary intervention.Ⅰ:history and development.BMJ 2003;326(7398):1080-1082
  • 6Fischman DL,Leon MB,Baim DS,et al.A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease.Stent Restenosis Study Investigators.N Engl J Med 1994;331(8):496-501
  • 7Eisenberg MJ,Konnyu KJ.Review of randomized clinical trials of drug-eluting stents for the prevention of in-stent restenosis.Am J Cardiol 2006;98(3):375-382
  • 8Yan BP,Ajani AE,Waksman R.Drug-eluting stents for the treatment of in-stent restenosis:a clinical review.Cardiovasc Revasc Med 2005;6(1):38-43
  • 9Nakatani M,Takeyama Y,Shibata M,et al.Mechanisms of restenosis after coronary intervention:difference between plain old balloon angioplasty and stenting.Cardiovasc Pathol 2003;12(1):40-48
  • 10Kornowski R,Hong MK,Tio FO,et al.In-stent restenosis:contributions of inflammatory responses and arterial injury to neointimal hyperplasia.J Am Coll Cardiol 1998;31(1):224-230

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心脏杂志
2004年 第5期

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