摘要
目的 初步探讨人肺腺癌多药耐药细胞系SPC A1/TAX的耐药机制。方法 免疫组织化学S P染色法检测多药耐药基因mdr1的表达产物P 糖蛋白 (P gp)。结果 在人肺腺癌多药耐药细胞系SPC A1/TAX与其亲本细胞系SPC A1中P gp的表达均为阴性。结论 该多药耐药细胞系的多药耐药性 (MDR)表型可能是非P
Objective To explore the mechanism of multi-drug resistance(MDR) in the human lung adenocarcinoma MDR subline SPC-A1/TAX.Methods The expressions of P-glycoprotein(P-gp)in these two cell lines were detected by immunocytochemistry staining.Results The immunocytochemistry staining of P-gp showed negative in both cell lines.Conclusion The human lung adenocarcinoma MDR subline SPC-A1/TAX is probably a non-P-gp MDR cell line.
出处
《江西医学院学报》
2004年第5期23-24,共2页
Acta Academiae Medicinae Jiangxi
关键词
人肺腺癌细胞系
多药耐药性
紫杉醇
P-糖蛋白
human lung adenocarcinoma cell line
multidrug resistance
paclitaxel
P-gp
