摘要
目的 了解纳洛酮与氨茶碱联合使用治疗早产儿原发性呼吸暂停的临床疗效。方法 用氨茶碱后仍出现呼吸暂停的早产儿 6 4例 ,随机分为例对照组和治疗组各 32例 ,治疗组加用纳洛酮 ,首次按 0 .0 5～ 0 .1mg/kg静脉注射 ,随后改为 0 .0 3～ 0 .0 5mg/kg·h-1静脉泵入 ,持续 5～ 6h ,连用 3d ,或用至症状明显好转时。比较两组间原发性呼吸暂停的时间和发生次数、心率、氧分压 (PaO2 纳洛酮 )和二氧化碳分压 (PaCO2 )等差异。结果 两组比较 ,治疗组患儿呼吸暂停的次数为 (1.94± 0 .6 2 )次 /dvs(3.0 9± 0 .81)次 /d ,P <0 .0 1;呼吸暂停的时间明显缩短 ,为 (19.2 5± 1.88)svs(2 3.38± 1.93)s,P <0 .0 1;呼吸暂停时PaO2 的下降程度 [(7.5 0± 0 .4 4 )kPavs(6 .4 1± 0 .39)kPa]及呼吸暂停时PaCO2 上升程度 [(6 .19± 0 .35 )kPavs(6 .6 7± 0 .39)kPa]及心率下降程度 [(96 .2 5± 9.0 7)次 /minvs (86 .88± 8.96 )次 /min]均明显减轻 ,P均 <0 .0 1。治疗组总有效率明显优于对照组 χ2 =7.73,P <0 .0 1。结论 纳洛酮与氨茶碱联合使用治疗早产儿原发性呼吸暂停疗效明显 。
Objective To investigate the clinical curativeness of naloxone plus aminophylline in treatment of primary apnea of preterm infants.Methods Sixty-four cases of preterm infants with primary apnea after administration of aminophylline were randomly divided into two groups: control group and treatment group. In the treatment group naloxone was added with an initial dose was 0.05～0.1 mg/kg intravenously, followed by 0.03～0.05 mg/kg·h pumped constantly into intravenously for 5～6 hours and continuously for 3 days or till obvious symptom improvement. The differences of duration,episodes,PaO 2,PaCO 2 and heart rate of primary apnea of preterm infants between two groups were compared.Results It showed that episodes of apnea [( 1.94 ±0.62)/d vs(3.09±0.81)/d]were greatly reduced in treatment group(P<0.001),and duration of apnea was significantly shorted [ (19.25±1.88)s vs(23.38±1.93)s,P<0.001].PaO 2[(7.50±0.44)kPa vs(6.41±0.39) kPa] and heart rate[(96.25±9.07) times /min vs( 86.88 ±8.96) times /min]]were alleviated,both P<0.001.While,PaCO 2[(6.19±0.35)kPa vs ( 6.67 ±0.39)kPa]were greatly reduced(P<0.001).The total effective rates of the treatment group were 87.50% and those in the control group were 56.25%(P<0.01).Conclusion Naloxone plus Aminophylline is worthy applied in primary apnea of preterm infants.
出处
《江西医学院学报》
2004年第5期62-64,共3页
Acta Academiae Medicinae Jiangxi
