摘要
目的 探讨高能聚焦超声刀加氟脲嘧啶、四氢叶酸治疗晚期胰腺癌临床疗效及毒副作用。方法 30例经病理学或细胞学确诊的晚期胰腺癌病人先用高能聚焦超声刀 (HIFU)治疗 ,再予氟脲嘧啶、四氢叶酸联合化疗。氟脲嘧啶 5 0 0mg/m2 加入 5 %GNS5 0 0ml静滴持续 6小时以每天 1次连用 5天 ,CF(四氢叶酸 ) 10 0mg/m2 加入生理盐水 2 5 0ml静滴每天 1次连用 5天 ,2 8天为 1周期 ,至少治疗 2个周期。结果 CR 1例 ;PR 9例 ;MR 9例 ;NC 5例 ;PD 6例。总有效率 6 3%。毒副作用主要消化道反应 ,其他副作用轻微。结论 应用HIFU局部治疗胰腺癌同时合用四氢叶酸加氟脲嘧啶全身化疗近期疗效提高明显 ,止痛明显达 75 % ,副反应小 ,值得应用。
Objective To evaluate the clinical effects and to xi y of treatment with local treated by High intensity Focused ultrasound (HiFu)fol lowed by ehemotherapy with combinations of 5-Fu and CF in advanced carcinoma of the pancreas. Methods Thirty pathologically and cytologically pro ved cases of carcinoma of the pancreas treated with HiFu followed by chemotherap y with combinations of 5-Fu and CF.5-Fu and CF were given at fixed doses 5-Fu 50 0mg/m2 infused over 6 hours on d1-5,CF 100mg/m2 infused on d1-5 The cycle wa s 28day.Eeach patient was treated at least two cycles.Results It showed CR one patient; PR nine pantients; MR nine pantients;Ns five panteents;PD six pantients; overall effective rate of 63% The main side effects was gastroin testinal reaction and other side effects were mild. Conclusions A high recent response rate is obtained carcinoma of the pancreas treated by loca l treatment with HiFu followed by chemotherapy with combinations of 5-Fu and CF, the rate of curing pain is 75%.The toxicity is mild.
出处
《齐齐哈尔医学院学报》
2004年第9期977-978,共2页
Journal of Qiqihar Medical University
