摘要
目的探讨孕母患自身免疫性甲状腺疾病对婴儿甲状腺功能的影响。方法通过浙江省新生儿疾病筛查网络系统,从2001年7月～2003年6月对78例母亲患自身免疫性甲状腺疾病的婴儿甲状腺功能进行追踪观察,采用病例对照分析的方法对可能影响婴儿甲状腺功能的因素进行非条件logistic回归分析。结果(1)78例孕母患自身免疫性甲状腺疾病的婴儿,其甲状腺功能正常37例,先天性甲低7例,甲亢1例,高TSH血症33例,与同期健康母亲的婴儿相比差异有显著性。(2)经多因素非条件logistic回归分析筛选出孕期母亲甲状腺功能状态、孕母患自身免疫性甲状腺疾病的种类、婴儿体内TSH受体抗体(TRAb)与婴儿甲状腺功能异常有关(均P<0.05)。结论孕母患自身免疫性甲状腺疾病对婴儿甲状腺功能有影响。为减少婴儿甲状腺功能异常的发生率,必须加强孕母妊娠期甲状腺功能的监测。
Objective To investigate the thyroid function of infants whose mothers suffered from autoimmune thyroid diseases. Methods From July 2001 to June 2003, the thyroid function of 78 infants born by mothers with autoimmune thyroid disease were followed up via provincial neonatal disease screening network system and the affecting factors on infant thyroid function were analysed by means of multiple factors unconditional logistic regression. Results (1) Among the 78 infants, 37 infants showed normal thyroid function, 33 hyperthyrotropinemia, 7 cases congenital hypothyroidism and one case was diagnosed as hyperthyroidism. These findings were significantly different from those in the screened infants born by healthy mothers during the same period of time. (2) By multiple factors unconditional logistic regression, the levels of thyrotropin receptor antibodies in infants, maternal thyroid function and the types of autoimmune thyroid disease during pregnancy were the risk factors for infant dysthyroidism (all P<0.05). Conclusion Maternal autoimmune thyroid diseases may affect infant thyroid function. Therefore, it is essential to focus on maternal thyroid function during conception in order to minimize the morbidity of infant dysthyroidism.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2004年第4期307-310,共4页
Chinese Journal of Endocrinology and Metabolism
基金
浙江省教育厅科技基金资助项目(20010532)
