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伊贝沙坦治疗早期糖尿病肾病的临床研究 被引量:8

A clinical study of irbesartan in treating early diabetic nephropathy
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摘要 63例早期糖尿病肾病患者,随机分为对照组和伊贝沙坦组。治疗12周,伊贝沙坦组HbA1c、尿白蛋白排泄率、尿β2微球蛋白、血清一氧化氮和血浆内皮素1水平均有明显下降,提示伊贝沙坦可延缓糖尿病患者肾功能损害。 Sixty-three type 2 diabetic patients with early diabetic nephropathy were randomly divided into control group and irbesartan treatment group. HbA_(1c), urinary albumin excretion rate and urinary β_(2)-microglobulin excretion, serum nitric oxide and plasma endothelin-1 levels in irbesartan treatment group were significantly decreased after 12 weeks treatment.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2004年第4期328-329,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 伊贝沙坦 治疗早期 糖尿病肾病 临床研究 HBA1C 尿白蛋白排泄率 延缓 水平 Irbesartan Diabetic nephropathies Endothcrin-1 Nitric oxide
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参考文献3

  • 1Parving HH, Lehnert H, Brochner-Mortensen J, et al. The effect of Irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med, 2001,345:870-878.
  • 2Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med, 2001,345:851-860.
  • 3Leppluoto J, Ruskoaho H. Endothelin peptides biological activities, cellular signalling and clinical significance. Ann Med, 1992,24:153-161.

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