摘要
目的 探讨胸腺上皮细胞的异质性及甲状腺功能降低时大鼠胸腺上皮细胞的变化。方法 将断乳后 1月的Wistar大鼠分为 2组 :正常组饲以正常饲料 ,饮用自来水 ;低碘组饲以低碘饲料 ,饮用去离子水。饲养 3个月后测定各组大鼠血清甲状腺素及胸腺指数 ,同时对大鼠胸腺进行透射电镜观察。结果 低碘组大鼠血清甲状腺激素及胸腺指数显著降低。胸腺上皮细胞发生了 3种变化 :( 1)细胞角蛋白增多 ;( 2 )囊泡增大和 (或 )小泡增多 ;( 3 )细胞降解。
Objectives To study the heterogenecity of thymic epithelial cells and their reactions to thyroid hormone deficiency.Methods Wistar rats,1 month after stopping laction,were divided into 2 groups.Normal group was fed with normal-iodine food and drink tap water.Low iodine group was fed with low-iodine food and drink deicon water.Three months later,thyroid hormone in serum,thymic index were measured and thymic epithelial cells were observed by electron microscopy.Results Thyroid hormone and thymic index decreased drastically in low iodine group.Thymic epithelial cells had three kinds of drastic changes on ultrastructure:(1)Tonofilaments increased significantly;(2)Many vacuoles and vesicles could be seen;(3)Degeneration of cell membrane.Conclusions Thymic eithelial cells in different area have various reactions to thyroid hormone deficiency.
出处
《中国地方病防治》
2004年第5期261-264,共4页
Chinese Journal of Control of Endemic Diseases
基金
国家自然科学基金重点资助项目 (No .30 2 30 330 )
天津医科大学科研资助项目 (No .2 0 0 1KY34)
