摘要
目的:建立紫外分光光度法测定艾拉莫德片溶出度的方法。方法:以磷酸盐缓冲液(pH 8.0)1000 mL为溶出介质,转速75 r·min-1,紫外分光光度法测定溶出量,检测波长257 nm。结果:在1.04-16.7μg·mL-1范围内呈良好的线性关系,r=0.9999,精密度RSD为0.3%(n=6)。结论:本方法简便、准确,可用于艾拉莫德片剂的溶出度测定。
Objective: To establish a method of dissolution of Iguratimod tablets by UV method. Method; A 1000 mL of pH 8. 0 phosphate buffer was used dissolution medium and apparatus was operated at the rate of 75 r · min-1. A UV method was used. The detection wavelength was at 257 nm. Results: There was a good linear relationship whin the range of 1.04-16. 7 μg · mL-1(r=0. 9999). The RSD of the method was 0. 7% (n =8). Conclusion; The method is accurate and convenient, and can be used for detection of dissolution of the Iguratimod tablets.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2004年第5期526-528,共3页
Chinese Journal of Pharmaceutical Analysis
