摘要
目的 :研究多发性骨髓瘤 (MM)患者的肝炎病毒的感染情况及临床特点的关系。方法 :应用ELISA法测定MM患者及 186名体检人员的甲、乙、丙、丁、戊、庚型肝炎病毒 (HAV、HBV、HCV、HDV、HEV、HGV)的标记物。结果 :5 6例MM患者中有 16例感染肝炎病毒 (占 2 8 5 7% ) ,其中HBV感染者 8例 (占 14 2 9% ) ,HCV感染者 4例 (占 7 14 % ) ,HEV感染者 1例 (占 1 79% ) ,HGV感染者 2例 (占 3 5 7% ) ,HEV与HGV均有感染者 1例 (占 1 79% ) ,HAV及HDV无感染者。这 16例患者肝功能改变的有 4例。 186例体检人员中 1例感染HCV(占 0 5 4 % )。结论 :MM患者中肝炎病毒的感染率高于一般人群 ,以HBV、HCV感染最高 ,且肝炎病毒感染的MM患者一般处于隐性感染阶段。
Objective:To study the infection and clinical feature of hepatitis virus in multiple myeloma(MM).Methods:The markers of hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV),hepatitis E virus (HEV), hepatitis G virus (HGV) were detected in 56 MM and 186 normal population by ELISA respectively.Results:Sixteen cases (28.5%) with MM had the evidence of hepatitis virus infection, among which 4 cases had liver dysfunction. Eight cases (14.29%) with HBV infection, four cases (7.14%) with HCV infection, one case (1.79%)with HEV infeteion, two cases(3.57%) with HGV infection, one case with both HEV and HGV infection in MM and one of 186(0.54%) normal population had the evidence of HCV infection respectively.Conclusion:The frequence of hepatitis virus infection in MM is higher than that in normal population, and the HBV and HCV infectious frequency is the highest. Moreover, the hepatitis infection cases in MM are in the stage of recessive infection.
出处
《临床肿瘤学杂志》
CAS
2004年第5期466-468,共3页
Chinese Clinical Oncology
