摘要
目的 评价戊二醛(GA)处理的牛心包作为引导骨组织再生材料的可行性。方法 在11只狗的双侧下颌骨颊侧骨板各制备一个1.0cm×1.0 cm×0.5 cm大小的骨缺损,随机在一侧骨缺损覆盖GA牛心包,另一侧不覆盖膜作为对照侧。术后2周,4周,8周,16周采用Demal-CT及组织学切片观察骨缺损修复情况。结果 ①10只狗伤口愈合良好,1只狗(16周组)牛心包处理区伤口愈合欠佳;②16周内牛心包未见明显吸收,周围仅少量炎性细胞浸润;③牛心包覆盖侧骨缺损修复速度快于对照侧。结论 ①GA牛心包有良好的引导骨组织再生作用,牛心包有可能成为一种新的引导骨组织再生材料;②GA处理的牛心包有良好的生物相容性。
Objective To explore the feasibility of bovine pericardium used as a material for guiding bone regeneration. Methods 1 cm ×1 cm ×0.5 cm defects were created on both buccal sides of the mandibles of 11 dogs. One side was covered with Gl-utaraldehyde (GA) cross-linking bovine pericardium; no membrane covered side was used as control. The animals were sacrificed in 2 weeks, 4 weeks, 8 weeks and 16 weeks after operation to observe the repair of the bone defects. Results ?Wounds healed well in 10 dogs. Meanwhile, wounds in dogs of 16 weeks group healed badly and severe inflammatory response was found in bovine pericardium treated area. ②The pericardium can be maintained in vivo for 16 weeks without absorption, there were only mild inflammatory cells invading. ③The bone defects covered with bovine pericardium repaired better than control groups significantly. Conclusion ①GA bovine pericardium have the effect on guiding bone regeneration in the repair of dog experimental bone defects and it is possible that the bovine pericardium will be used as a new kind of GBR material; 瓽A bovine pericardium has good bio-compatibibty.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2004年第5期429-431,共3页
West China Journal of Stomatology
基金
湖南省科技厅基金资助项目(02JJY1004)
