摘要
目的 探讨CD44V 6、E cadherinhe和nm 2 3 H 1蛋白表达与肾细胞癌 (RCC)的发生、发展及转移的关系。方法 采用免疫组化SP方法 ,检测 46例肾细胞癌组织和 10例正常肾组织中CD44V 6、E cadherin和nm 2 3 H 1蛋白的表达情况。结果 CD 44V 6蛋白在肾细胞癌组织中的阳性表达率为 2 6.1% ,CD 44V 6高表达与肾细胞癌脉管浸润转移呈正相关 (P <0 .0 5 )。nm 2 3 H 1和E cadherin蛋白在肾细胞癌组织中阳性表达率分别为 2 3 .9%和 5 8.7% ,显著低于正常肾组织 ( 10 0 .0 % ) (P <0 .0 1)。nm 2 3 H 1和E cadherin阳性表达与肾细胞癌的组织学分级相关 (P <0 .0 5 )。CD 44V 6、E cadherin、nm 2 3 H 1阳性表达与肾细胞癌组织学分型和肿瘤大小无关 (P >0 .0 5 )。结论 CD44V 6蛋白高表达和E cadherin、nm 2 3 H 1蛋白低表达是判断肾细胞癌的生物学行为的良好指标。
Objective To study the relationship between the expression of CD44V6?E-cadherin and nm23-H1 protein and the clinicopathological characteristics in human renal cell carcinoma(RCC).Methods The expression of CD44V6?E-cadherin and nm23-H1 protein were detected in 46 cases of renal cell carcinoma tissue and 10 cases of normal kidney tissue with S-P immunohistochemical method.Results The over expression of CD44V6 protein in RCC had a significant positive correlation with vascular invasion(P<0.05).But the positive expression of E-cadherin and nm23-H1 protein in RCC was significantly lower than that in normal kidney tissue(P<0.01),showing a positive correlation with histological grade of the RCC(P<0.05).No significant relationship was found between the positive expression rates of CD44V6?E-cadherin?nm23-H1 protein and the size?histopathological type of RCC(P>0.05).Conclusion The over expression of CD44V6 and the low-expression of E-cadherin and nm23-H1 may be good indicators for predicting metastasis and the prognosis of RCC.
出处
《实用癌症杂志》
2004年第4期357-360,共4页
The Practical Journal of Cancer
