摘要
目的:评价低分子肝素(low-molecularweightheparin,LMWH)与其他药物改善急性脑梗死(acutecerebralinfarction,ACI)患者运动功能的疗效差异及安全性。方法:应用Meta分析方法对LMWH与其他药物治疗ACI的14项对照研究进行同质性检验和合并效应量的检验。结果:①同质性检验:χ2=15.05,自由度为13,P>0.05。②合并效应量的检验:OR合并=3.0850,OR合并95%可信区间为2.35～4.04。OR合并的检验:χ2=66.38,P<0.001。③LMWH组共发生注射局部皮下出血71例(8.9%),上消化道出血11例(1.4%),牙龈出血4例(0.5%),阴道出血4例(0.5%),血尿1例(0.1%);对照组发生上消化道出血6例(0.9%),与LMWH组比较差异无显著性意义(P>0.05)。④LMWH组治疗前后出、凝血时间,血浆凝血酶时间,活化部分凝血活酶时间,血小板计数及肝功能检查均正常。结论:LMWH改善ACI患者运动功能的疗效显著优于目前常用药物,且无严重不良反应。
AIM:To assess the effective differences between low-molecular weight heparin(LMWH) and other drugs in the amelioration of motor function in patients with acute cerebral infarction(ACI) and the safety of LMWH. METHODS:Fourteen control trials of LMWH and other drugs in the treatment of ACI were analyzed by Meta-analysis in homogeneity test and combined test. RESULTS:①Homogeneity test: χ2 =15.05,degree of freedom 13,P >0.05.②Combined test:OR combination=3.085 0 and OR combination 95%confidence interval was between 2.35 to 4.04. OR combination test:χ2=66.38,P< 0.001.③In LMWH group,the hemorrhage rate under skin in injected location was 8.9%(71 patients),upper gastrointestinal hemorrhage rate was 1.4%(11 patients),gingival hemorrhage rate was 0.5%(4 patients), vaginal hemorrhage rate was 0.5%(4 patients),and hematuria rate was 0.1%(1 patient).In control group, upper gastrointestinal hemorrhage rate was 0.9%(6 patients), which was not significantly different from that in LMWH group(P >0.05).④In LMWH group,measurement of bleeding time,clotting time, prothrombin time(PT),activated partial thromboplastin time(APTT),platelet count and liver function test were normal before and after treatment. CONCLUSION:The therapeutic effects of LMWH on motor function for ACI patients are significantly superior to other medications used at present,and it has not serious side effects.
出处
《中国临床康复》
CAS
CSCD
2004年第31期6840-6842,共3页
Chinese Journal of Clinical Rehabilitation
