摘要
目的 了解北京地区正常妊娠 (NG)、妊娠糖耐量受损 (GIGT)、妊娠糖尿病 (GDM )孕妇的糖耐量水平。 方法 5家医院联合前瞻性对 94 8名孕妇在孕 2 4～ 32周间先行 5 0 g糖筛查试验 ,不管其值高低均于 3d后行口服葡萄糖耐量试验 (OGTT)。 结果 OGTT按美国国家糖尿病资料组 (NDDG)标准判断正常组 5 34名 ,取其 4次血糖值的第 97 5百分位数为 5 2 8、9 75、6 6 1和6 78mmol/L。OGTT中 1项异常或 2h血糖值在 6 6 7～ 9 11mmol/L之间为GIGT组 372名 ,第97 5百分位数血糖值为 6 0 6、11 89、9 6 1、和 8 0 0mmol/L。GDM组 4 2例 ,其中 33例根据OGTT 4项值中≥ 2项异常确诊 ,其血糖值为 8 0 0、16 89、14 4 4和 11 6 7mmol/L。 结论 正常孕妇OGTT第 97 5百分位数的血糖值低于国内外报道。目前应用的NDDG诊断标准是否过高导致假阴性 。
Objective To investigate the glucose tolerance le vel among pregnant women in Beijing. Methods After 50 g g lucose challenge test (GCT) was done, a prospective study of 75 g oral gluco se tolerance test (OGTT) in 948 pregnant women between 24～32 gestational weeks w as done in five hospitals so as to investigate the glucose tolerance levels in n ormal, GIGT, GDM women. Results By the judgement of diagn ostic criteria of NDDG, 534 patients’OGTT were normal. The 97.5 th perce ntage of their plasma glucose level (mmol/L) were 5.28, 9.75, 6.61 and 6.78 . The 372 GIGT patients were diagnosed by OGTT, the glucose levels were 6.06, 11.89 ,9.61 and 8.00 mmol/L. 42 patients were GDM and 33 of them were di agnosed by OGTT. Their plasma glucose levels in 97.5 th percentage were 8 .00,16.89,14.44 and 11.67 mmol/L. Conclusions The 97.5 th percentages of OGTT in normal pregnant women are lower in our study than those in domestic and international reports. It needs further research to d etermine if the present NDDG diagnostic standard were too high so that it will i ncrease false negative rate.
