摘要
目的 :探讨胃肠粘膜相关 (MALT)淋巴瘤中细胞凋亡特点及其与NF κB表达的关系。方法 :收集 10例胃肠道粘膜相关淋巴组织 (MALT)和 4 0例胃肠MALT淋巴瘤 ,以免疫组化方法检测NF κB表达 ,以TUNEL法进行细胞凋亡检测。结果 :MALT组、低度恶性MALT淋巴瘤组和低高混合恶性MALT淋巴瘤组凋亡指数 (AI)分别为 (2 36 0±0 4 0 3) %、(1 6 32± 0 82 0 ) %、(1 12 2± 0 6 78) %。MALT组AI显著高于MALT淋巴瘤组 (P <0 0 1) ;NF κB阳性率分别为 30 0 %、6 1 3%和 88 9% ,三组表达间差异有显著性 (P <0 0 1)。AI与NF κB表达呈负相关 (r =- 0 716 ,P <0 0 1)。结论 :NF κB激活引起凋亡抑制在MALT淋巴瘤发生发展中可能起重要作用。
Objective: To identify the apoptotic cells in gast ro intestinal MALT lymphoma and its relationship with NF-κB Protein expression. Methods: Ten gastrointestinal mucosa associated lymphoid tissues (M ALT) and 40 gastrointestinal MALT lymphomas were enrolled. Immunohistochemical s taining and apoptosis by TUNEL were carried out in all cases. Results: Apoptotic indices (AI) in MALT were significantly higher than those in MALT lymphoma (P<0.01), NF-κB was expressed in 30.0% of MALT, 61.3% of th e Low-grade tumors and 88.9% of mixed-grade tumors. The positive rate of NF -κB was significantly increased as the histological grade advanced (P<0.0 1).There was an inverse correlation between AI and the expression of NF-κB amo ng all cases (r=-0.716,P<0.01). Conclusion: Apoptosis inhibi tion by overexpression of NF-κB might be involved in the onset and process of MALT lymphoma [
出处
《江苏大学学报（医学版）》
CAS
2004年第5期378-380,F005,共4页
Journal of Jiangsu University：Medicine Edition
基金
江苏省自然科学基金资助 (NOBK9915 0 )
