摘要
目的 探讨急性冠脉综合征 (ACS)、稳定型心绞痛 (SAP)患者血浆血脂、氧化低密度脂蛋白 (OX-L DL)及其抗体 (Anti- OX- L DL)变化在冠状动脉粥样硬化 (AS)发生、发展中的作用及其相关性。方法 分别用酶联免疫吸附法测定 136例冠心病 (ACS组 10 6例 ,SAP30例 )及 5 6例正常对照组的血浆血脂、OX- L DL、Anti- OX-L DL,并进行直线相关性分析。结果 1冠心病组血脂 TC、TG、L DL- C与对照组存在显著差异 (P<0 .0 1)。 2ACS组血浆 OX- L DL及 Anti- OX- L DL与 SAP组、对照组比较 ,P均 <0 .0 1;SAP组与对照组比较上述指标差异无显著性 (P>0 .0 5 )。 3ACS组 OX- L DL与 L DL呈正相关 (r=0 .6 4 2 ,P<0 .0 1) ;Anti- OX- L DL与 L DL无关 (r=0 .341,P>0 .0 5 )。结论 高脂血症是冠心病的绝对危险因素 ;OX- L DL及其抗体在 ACS发病中起重要作用 ;Anti- OX- L DL 作用不依赖于 L DL。
Objective To observing changes of plasma LP,OX-LDL and Anti-OX-LDL in 106 patients with acute coronary syndrome(ACS),30 patients with stable angina pectoris (SAP) and 56 control cases.Methods The plasma levels of LP,OX-LDL and Anti-OX-LDL were measured with enzyme linked immunosorbent assay (ELISA) method respectively,The analysis of linear correlation was performed to estimate the relationship between variables.Results ①Plasma total cholesterol (TC),triglycerides (TG) and low density lipoprotein (LDL) were significant difference between coronary heart disease group and control group respectively (P<0.01).②Plasma OX-LDL and Anti-OX-LDL were significant different between ACS group and SAP group,control group respectively (P<0.01),there was no significant different between SAP group and control group (P>0.05).③Linear correlation analysis showed that ACS plasma OX-LDL in patients with was positively correlated with LDL(r=0.642,P<0.01),but plasma Anti-OX-LDL had no relationship with LDL(r=0.341 P>0.05).Conclusion Plasma LP is the absolute risk factor of CHD.OX-LDL and Anti-OX-LDL play important role in the incidence of AS and heart event.Anti-OX-LDL has independent role.
出处
《山东医药》
CAS
北大核心
2004年第31期4-5,共2页
Shandong Medical Journal
