摘要
目的 探讨肝硬化患者纤溶活性增高与组织纤溶酶原激活物 (t- PA)、组织纤溶酶原激活物抑制剂(PAI)的关系。方法 根据 Child- Pugh分级将确诊为肝硬化的 86例患者分为三组 ,A级组 2 6例 ,B级组 30例 ,C级组 30例。均检测 t- PA、PAI、纤维蛋白 (原 )降解产物 (FDP)和 D-二聚体。结果 三组 t- PA抗原随病情严重程度而显著性升高 ,有显著性差异 (P<0 .0 5 ) ;PAI活性三组近似 (P>0 .0 5 ) ;纤溶活性高者的 t- PA略高于正常纤溶者 ,且二者 PAI近似 ,均无显著性差异 (P>0 .0 5 )。结论 t- PA随病情加重而显著性升高 ,PAI随病情加重变化不大 ;t- PA、PAI失平衡不是肝硬化患者纤溶活性升高的主要因素。
Objective To investigate the relationship between hyperfibrionlysis and tissue plasminogen activator antigen (t-PA),plasminogen activator inhibitor activity (PAI) in patients with different degrees of cirrhosis associated with viral hepatitis.Methods Eighty-three patients (70 men,16women;age:25~71yr)with cirrhosis were divided into three subgroups(A,B and C) on the basis of Child-Pugh classification.Tissue plasminogen activator antigen (t-PA),plasminogen activator inhibitor activity (PAI),fibrin/fibrinogen degradation products (FDP) and fragment D-dimer were measured in each patients.Results We noted progressive increase of t-PA antigen from A to C class(P<0.05).This increase was significantly related to prothrombin time,bilirubin,albumin.whereas PAI activity did not display significant changes (P>0.05).Conclusion The levels of t-PA and PAI of patients with hyperfibrinolysis were not significantly higher than normal fibrinolysis,suggesting that the t-PA/PAI imbalance was not a main cause of hyperfibrinolysis in patients with cirrhosis.
出处
《山东医药》
CAS
北大核心
2004年第31期12-13,共2页
Shandong Medical Journal
基金
北京市科委重大科技项目 ( No.2 0 92 0 0 2 0 2 90 )
